AI Article Synopsis
- Chronic obstructive pulmonary disease (COPD) is increasingly common among older adults and is characterized by an inflammatory response.
- A specific population of blood cells affected by genetic changes, known as clonal hematopoiesis of indeterminate potential (CHIP), has been studied for its link to COPD, though its effects are not well understood.
- Research on 125 COPD patients revealed that about 20% had CHIP mutations, particularly linked to decreased DNA methylation in a gene associated with lung function, leading to higher levels of harmful substances and inflammation.
Article Abstract
Chronic obstructive pulmonary disease (COPD) is a disease with an inflammatory phenotype with increasing prevalence in the elderly. Expanded population of mutant blood cells carrying somatic mutations is termed clonal hematopoiesis of indeterminate potential (CHIP). The association between CHIP and COPD and its relevant effects on DNA methylation in aging are mainly unknown. Analyzing the deep-targeted amplicon sequencing from 125 COPD patients, we found enhanced incidence of CHIP mutations (~20%) with a predominance of DNMT3A CHIP-mediated hypomethylation of Phospholipase D Family Member 5 (), which in turn is positively correlated with increased levels of glycerol phosphocholine, pro-inflammatory cytokines, and deteriorating lung function.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9265467 | PMC |
| http://dx.doi.org/10.3390/cells11132121 | DOI Listing |
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