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Neurotrophins in Zebrafish Taste Buds. | LitMetric

Neurotrophins in Zebrafish Taste Buds.

Animals (Basel)

Department Agricultural Sciences, University of Naples Federico II, Via Università 100, 80055 Portici, Italy.

Published: June 2022

AI Article Synopsis

  • The neurotrophin family includes NGF, BDNF, NT3, and NT4, which are crucial for nerve development and maintenance through specific receptors.
  • This study aims to determine the presence of these neurotrophins in zebrafish taste buds, utilizing morphological analyses to support the investigation.
  • Findings indicate that these neurotrophins are present in zebrafish sensory cells, particularly identifying BDNF as dominant in certain areas, highlighting zebrafish as a valuable model for understanding neurotrophin functions.

Article Abstract

The neurotrophin family is composed of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), Neurotrophin 3 (NT3) and NT4. These neurotrophins regulate several crucial functions through the activation of two types of transmembrane receptors, namely p75, which binds all neurotrophins with a similar affinity, and tyrosine kinase (Trk) receptors. Neurotrophins, besides their well-known pivotal role in the development and maintenance of the nervous system, also display the ability to regulate the development of taste buds in mammals. Therefore, the aim of this study is to investigate if NGF, BDNF, NT3 and NT4 are also present in the taste buds of zebrafish (), a powerful vertebrate model organism. Morphological analyses carried out on adult zebrafish showed the presence of neurotrophins in taste bud cells of the oropharyngeal cavity, also suggesting that BDNF positive cells are the prevalent cell population in the posterior part of the oropharyngeal region. In conclusion, by suggesting that all tested neurotrophins are present in zebrafish sensory cells, our results lead to the assumption that taste bud cells in this fish species contain the same homologous neurotrophins reported in mammals, further confirming the high impact of the zebrafish model in translational research.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9265000PMC
http://dx.doi.org/10.3390/ani12131613DOI Listing

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