This paper presents the equivalence between generalized proportional integral observer (GPIO) and disturbance observer (DOB), which is applicable to reduced-order GPIO (ROGPIO), full-order GPIO (FOGPIO), and extended state observer (ESO). From this equivalence, established in frequency-domain, comprehensive analyses are performed regarding the influence of the system order, the number of extended states, the uncertain control gain, and the tuning method on the robustness and performance of GPIO. In addition, the equivalence allows a detailed comparison between ROGPIO and FOGPIO in the active disturbance rejection control (ADRC) framework. Finally, experimental validation of the main results is presented for the study case of a synchronous buck converter.
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http://dx.doi.org/10.1016/j.isatra.2022.06.032 | DOI Listing |
World J Oncol
February 2025
Comprehensive Breast Health Center, Department of Surgery, Taipei Veterans General Hospital, Taipei 112201, Taiwan.
Background: While mutations in the gene play important roles in human breast carcinogenesis, gene alterations are recognized as actionable mutations for clinical cancer treatment. We aimed to elucidate the role of PIK3R1 in cell proliferation on breast carcinoma and to correlate the PIK3R1 expression with patients' outcome using human tumor tissue arrays.
Methods: Using human BT-474 (estrogen receptor (ER)+/human epidermal growth factor receptor 2 (HER2)-high) breast carcinoma cell line as model, the role of PIK3R1 in cell proliferation was elucidated by knock-down of the gene (ΔPIK3R1) in this cell line.
Cureus
December 2024
Department of Radiology, Aichi Medical University, Nagakute, JPN.
Purpose In linac-based stereotactic radiosurgery (SRS) utilizing a multileaf collimator (MLC) for brain metastases (BMs), a volumetric-modulated arc (VMA) technique is indispensable for generating a suitable dose distribution with efficient planning and delivery. However, the optimal calculation grid spacing (GS) and statistical uncertainty (SU) of the Monte Carlo algorithm for VMA optimization have yet to be determined. This planning study aimed to examine the impacts of GS and GU settings on VMA-based SRS planning and to find the optimal combination for templating.
View Article and Find Full Text PDFFood Res Int
February 2025
Department of Food Science, Federal University of Lavras 37200-900 Lavras, MG, Brazil.
Baru (Dipteryx alata Vogel), a fruit native to the Brazilian Cerrado, has gained scientific interest due to its nutritional potential and commercial value. Its edible seed, of high commercial value, represents around 5 % of the fruit. On the other hand, its pulp, a byproduct of the baru processing industry, is normally discarded, generating a huge volume of waste with reported antioxidant properties.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Electrical Engineering, College of Engineering, Taif University, Taif, 21944, Saudi Arabia.
This paper presents a novel approach to modeling and controlling a solar photovoltaic conversion system(SPCS) that operates under real-time weather conditions. The primary contribution is the introduction of an uncertain model, which has not been published before, simulating the SPCS's actual functioning. The proposed robust control strategy involves two stages: first, modifying the standard Perturb and Observe (P&O) algorithm to generate an optimal reference voltage using real-time measurements of temperature, solar irradiance, and wind speed.
View Article and Find Full Text PDFAnn Oncol
January 2025
Department of Surgery, Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, New York, United States. Electronic address:
Background: Prospective data comparing watch-and-wait (WW) to mandatory total mesorectal excision (TME) in patients with locally advanced rectal cancer (LARC) remains limited, as randomized control trials assessing these two treatment approaches are considered impractical. This pooled analysis of the CAO/ARO/AIO-12 and OPRA trials analyzes survival outcomes among LARC patients managed with either a selective WW or mandatory TME strategy following total neoadjuvant therapy (TNT).
Patients And Methods: The CAO/ARO/AIO-12 and OPRA trials were multicenter, phase II trials that randomized patients with stage II/III rectal cancer to receive either induction or consolidation chemotherapy as part of TNT.
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