Objectives: The risk of developing hand-arm vibration syndrome (HAVS) from occupational hand-arm vibration (HAV) exposure is traditionally determined by the onset of vascular symptoms (white fingers). However, changes in tactile sensibility at the fingertips is a clinical sign of HAVS which in most cases precedes vascular signs. We aimed to assess relationships between occupational HAV exposure and HAVS-related signs including vibration perception thresholds (VPT) and pegboard score on an individual level, using a longitudinal study design with follow-up tests.
Methods: We followed-up 148 workers exposed to different HAV levels for 4 years, with health examinations including VPT tests and pegboard tests carried out at baseline, 2 years and 4 years. VPT testing included seven frequencies, from 8 to 500 Hz. Second and fifth finger on both hands were tested, thus a total of 28 tests on each subject. We investigated associations using linear mixed models and significance level at p≤0.05.
Results: There was a significant exposure-response relationship on an individual level between HAV exposure from rock drills and VPT for 16 of 28 test frequencies. The highest rise (worsening) in VPT was found at the 500 Hz test frequency with 1.54 dB increased VPT per 10-fold increase in cumulative exposure. We found no deterioration in pegboard performance associated with HAV exposure among the participants.
Conclusions: Risk predictions of HAVS may be based on exposure-response relationships between HAV exposure and VPT. The 500 Hz test frequency should be included in the VPT test protocols for early detection of signs related to reduced tactile sensibility.
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http://dx.doi.org/10.1136/oemed-2022-108293 | DOI Listing |
Oncoimmunology
December 2025
Heidelberg University, Medical Faculty Heidelberg, Department of Dermatology and National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and University Hospital Heidelberg, Heidelberg, Germany.
Immune checkpoint blockers have substantially improved prognosis of melanoma patients, nevertheless, resistance remains a significant problem. Here, intrinsic and extrinsic factors in the tumor microenvironment are discussed, including the expression of alternative immune checkpoints such as lymphocyte activation gene 3 (LAG-3) and T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3). While most studies focus on immune cell expression of these proteins, we investigated their melanoma cell intrinsic expression by immunohistochemistry in melanoma metastases of 60 patients treated with anti-programmed cell death protein 1 (PD-1) and/or anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) therapy, and correlated it with the expression of potential ligands, RNA sequencing data and clinical outcome.
View Article and Find Full Text PDFToxicon
January 2025
Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai, 201203, China. Electronic address:
Vaccines (Basel)
November 2024
Vaccines for Africa Initiative, School of Public Health, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa.
There is limited evidence comparing hepatitis A seroprevalence among HIV-exposed uninfected (HEU), HIV-infected (HIV), and unexposed uninfected (HUU) children. This compromises rational vaccine decision-making. This study comprised a retrospective health facility-based population of children aged 1 month-12 years.
View Article and Find Full Text PDFmSphere
November 2024
Department of Civil and Environmental Engineering, Stanford University, Stanford, California, USA.
Ann Work Expo Health
January 2025
Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294-0022, United States.
Objective: The objectives of this study were to evaluate daily hand-arm vibration (HAV) exposure among groundskeepers, characterize power tools used, and estimate lifetime cumulative HAV exposure dose.
Methods: Seventeen groundskeepers and ten office workers employed at two US southeasterrn institutions were recruited as a target exposure group and a reference group, respectively. A 6-d exposure assessment of HAV was scheduled, and vibration dosimeters were used to obtain daily vibration exposure value, A(8).
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