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The exome is not the end, it is just the beginning: A mother's perspective on discovering a variant of uncertain significance in a normal pregnancy.
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Cadence Design Systems, Israel.
Resveratrol Alleviates the Prenatally Intermittent Hypoxia-Induced Cognitive Impairment in Male Offspring Mice Through Modulating the SIRT1/HIF-1α Pathway.
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Department of Neurology, Hefei Second People's Hospital Affiliated to Bengbu Medical University, Hefei, Anhui, China.
Objective: Growing evidence indicate that prenatal intermittent hypoxia (PIH) exposure can have an impact on the critical brain nerve development of the fetus, resulting in cognitive deficits in the offspring mice. Resveratrol, recognized for its anti-inflammatory and antioxidant capabilities, has potential to ameliorate synaptic dysfunction, which in turn may contribute to its positive influence on cognitive impairment. Nevertheless, the precise manner in which resveratrol mitigates cognitive deficits stemming from maternal hypoxia remains to be fully elucidated, including the specific mechanisms at play.
View Article and Find Full Text PDFDietary and related data collected during pregnancy in the Avon Longitudinal Study of Parents and Children (ALSPAC).
Wellcome Open Res
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Centre for Academic Child Health, Canynge Hall, University of Bristol Medical School, Bristol, England, UK.
The Avon Longitudinal Study of Parents and Children (ALSPAC) is a longitudinal birth cohort study based in the south-west of the UK. Pregnant women resident in and around the city of Bristol with expected delivery dates between 1 April 1991 and 31 December 1992 were invited to take part. The initial number of pregnancies enrolled was 14,541.
View Article and Find Full Text PDFAssociation between female waist-hip ratio and live birth in patients undergoing fertilization: a retrospective cohort study.
Front Endocrinol (Lausanne)
March 2025
Centre for Assisted Reproduction, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.
Background: Maternal obesity is associated with adverse pregnancy outcomes. It negatively affects IVF/ICSI outcomes and offspring health. However, it is unclear whether waist-hip ratio (WHR) has an impact on outcomes of fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycles.
View Article and Find Full Text PDFGushen Antai pill for expected normal ovarian responders undergoing IVF-ET (GSATP-FreET): interim analysis of a randomized controlled trial.
Contracept Reprod Med
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The First Clinical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
Introduction: Optimal luteal phase support (LPS) is essential for successful embryo transfer. In our previous study, we found that LPS combined with Gushen Antai pill (GSATP) could significantly improve ongoing pregnancy rate (OPR) and reduce threatened abortion rate after frozen-thawed embryo transfer (FET). Despite this, no high-quality studies have been performed on the combination of LPS and GSATP for the embryo transfer of fresh IVF cycles.
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