AI Article Synopsis
- Classical histone deacetylases (HDACs) are important enzymes involved in modifying histones and other proteins, and they are key drug targets for certain cancers.
- Class I HDACs (1-3) often form multiprotein complexes that have specific roles in regulating gene expression.
- Recent studies have advanced our understanding of the structure and enzymatic functions of various HDAC complexes, such as CoREST and NuRD, highlighting their unique catalytic activities and preferences when interacting with modified nucleosome substrates.
Article Abstract
Classical histone deacetylases (HDACs) are enzymes that can hydrolytically cleave acetyl-Lys in histones and other proteins and serve as established drug targets in some forms of cancer. Class I HDACs 1-3 typically exist in a range of multiprotein complexes inside cells and show distinct biological functions in modulating gene expression. In recent years, it has become possible to purify and analyze the structure and enzymatic properties of several of these HDAC complexes, including CoREST, MiDAC, NuRD, Sin3, SMRT, MIER, and RERE. Here, we summarize what is experimentally established and/or computationally predicted about the structure of these complexes to describe their particular catalytic activities and site-specificities with modified nucleosome substrates.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10786639 | PMC |
| http://dx.doi.org/10.1016/j.cbpa.2022.102179 | DOI Listing |
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