AI Article Synopsis
- TAMG is a subtype of Myasthenia gravis associated with specific proteins and metabolic processes that differentiate it from thymomas without myasthenia gravis.
- A comprehensive analysis involving proteomics and metabolomics was performed on serum samples from various thymoma groups to identify key proteins and metabolic pathways linked to TAMG.
- Results revealed several proteins associated with TAMG (+) thymomas and highlighted the connection between immune and metabolic systems in the disease's pathogenesis.
Article Abstract
Background: Thymoma-associated myasthenia gravis (TAMG) is a well-described subtype of Myasthenia gravis (MG). Nevertheless, the detailed proteins and bioprocess differentiating TAMG from TAMG (-) thymoma have remained unclear.
Methods: The proteomics and metabolomics were carried out on serum samples from thymoma group ( = 60, TNMG), TAMG (+) thymoma group ( = 70, TAMG (+)), and TAMG (-) thymomas group ( = 62, TAMG (-)), and controls ( = 159). groups. Proteomics and metabolomics analyses, including weighted gene co-expression network analysis (WGCNA), was conducted to detect the hub proteins and metabolomics processes that could differentiate TAMG (+) from TAMG (-) thymomas. MetaboAnalyst was used to examine the integration of proteomic and metabolomic analysis to differentiate TAMG (+) from TAMG (-) thymomas.
Results: The of module-trait correlation of WGCNA analysis identified KRT1, GSN, COL6A1, KRT10, FOLR2, KRT9, KRT2, TPI1, ARF3, LYZ, ADIPOQ, SEMA4B, IGKV1-27, MASP2, IGF2R was associated with TAMG (+) thymomas. In addition, organismal systems-immune system and metabolism-biosynthesis of other secondary metabolites were closely related to the mechanism of TAMG (+) pathogenesis.
Conclusion: Our integrated proteomics and metabolomics analysis supply a systems-level view of proteome changes in TAMG (+), TAMG (-) thymomas and exposes disease-associated protein network alterations involved in.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320536 | PMC |
| http://dx.doi.org/10.18632/aging.204156 | DOI Listing |
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