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COVID-19 therapeutics and outcomes among solid organ transplant recipients during the Omicron BA.1 era. | LitMetric

AI Article Synopsis

  • * It involved 154 SOTR patients with confirmed COVID-19 during the Omicron BA.1 wave, comparing those treated with specific therapies to those who received no treatment.
  • * Results indicated that patients receiving NR or sotrovimab had lower rates of hospitalization or death within 30 days compared to those without treatment, suggesting that these specific agents could be beneficial for SOTR patients.

Article Abstract

Treatment outcomes associated with the use of novel COVID-19 therapeutics in solid organ transplant recipients (SOTR) are not well described in the literature. The objective of this analysis was to characterize 30-day hospitalization and other key secondary endpoints experienced by outpatient SOTR with mild-moderate COVID-19 treated with nirmatrelvir/ritonavir (NR), sotrovimab, or no SARS-CoV-2 specific treatment. This IRB-approved, retrospective study included 154 SOTR with a documented positive SARS-CoV-2 infection between December 16, 2021 and January 19, 2022 (a predominant Omicron BA.1 period in New York City). Patients who received NR (N = 28) or sotrovimab (N = 51) experienced a lower rate of 30-day hospitalization or death as compared to those who received no specific treatment (N = 75) (p = .009). A total of three deaths occurred, all among patients who initially received no specific treatment prior to hospitalization. These results suggest a role for SARS-CoV-2 specific agents in the treatment of SOTR with COVID-19, and that there does not appear to be any difference in effectiveness when comparing NR versus sotrovimab.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9349644PMC
http://dx.doi.org/10.1111/ajt.17140DOI Listing

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