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| http://dx.doi.org/10.1016/j.idcr.2022.e01547 | DOI Listing |
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A1, an innovative fluorinated CXCR4 inhibitor, redefines the therapeutic landscape in colorectal cancer.
Cancer Cell Int
January 2025
Department of Immunology, School of Medicine, Iran University of Medical Sciences, Hemmat Ave, Tehran, Iran.
Background: Colorectal cancer (CRC) is a globally prevalent malignancy, primarily affecting the colon and rectum, characterized by uncontrolled cellular changes in the intestinal wall lining. Recent evidence underlines the significant role of the CXCL12/CXCR4 axis in the development of CRC, suggesting that inhibiting this pathway could be a promising therapeutic approach. This study focuses on investigating the potential of N, N''-thiocarbonylbis (N'-(3,4-dimethyl phenyl)-2,2,2-trifluoroacetimidamide) (A1), a novel fluorinated CXCR4 inhibitor, through a comprehensive analysis encompassing in silico, in vitro, and in vivo studies.
View Article and Find Full Text PDFColon-specific controlled release of oral liposomes for enhanced chemo-immunotherapy against colorectal cancer.
Acta Pharm Sin B
November 2024
School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
A colon-specific drug delivery system has great potential for the oral administration of colorectal cancer. However, the uncontrollable fate of liposomes makes their effectiveness for colonic location, and intratumoral accumulation remains unsatisfactory. Here, an oral colon-specific drug delivery system (CBS-CS@Lipo/Oxp/MTZ) was constructed by covalently conjugating spores (CBS) with drugs loaded chitosan (CS)-coated liposomes, where the model chemotherapy drug oxaliplatin (Oxp) and anti-anaerobic bacteria agent metronidazole (MTZ) were loaded.
View Article and Find Full Text PDFExploring Early Complications in Paraumbilical Hernia Mesh Repair: A Rigorous Six-Month Prospective Study and In-Depth Analysis.
Cureus
November 2024
General Medicine, Rehman Medical Institute, Peshawar, PAK.
Introduction When an organ, such as the colon, pushes through the wall of the abdominal cavity, a hernia results. After femoral and inguinal hernias, umbilical hernias account for the third most common kind of abdominal hernia in adults precipitated by conditions such as obesity, ascites, and repeated pregnancies. A subtype of umbilical hernias called paraumbilical hernias is more likely to cause problems such as rupture, skin ulceration, and obstruction.
View Article and Find Full Text PDFThe protumorigenic enzyme GPAT2 inhibits arachidonic acid-triggered apoptosis in breast cancer.
Lipids Health Dis
November 2024
Instituto de Investigaciones Bioquímicas de La Plata Dr. Rodolfo R. Brenner, Consejo Nacional de Investigaciones Científicas y Técnicas, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, La Plata, Buenos Aires, Argentina.
Background: Cancer is a significant health challenge and the leading cause of mortality globally. Tumor cells use multiple mechanisms to acquire their distinctive capacity for uncontrolled proliferation, one of which is the evasion of apoptosis. It has been shown that in breast, colon, and liver cancer, evasion of apoptosis is associated with the overexpression of enzymes that metabolize arachidonic acid (AA) because free AA is a strong inducer of apoptosis.
View Article and Find Full Text PDFCOMPARISON OF THE OUTCOMES OF ENHANCED RECOVERY AFTER SURGERY (ERAS) VS CONVENTIONAL CARE IN ELECTIVE COLORECTAL SURGERY.
J Ayub Med Coll Abbottabad
November 2024
Department of Surgery, Quaid-e-Azam Medical College, Bahawalpur-Pakistan.
Article Synopsis
- - Colorectal cancer, arising from uncontrolled cell growth in the colon, rectum, or appendix, is more common in developed countries and often occurs in individuals with no significant genetic risk; the study investigates the effectiveness of Enhanced Recovery After Surgery (ERAS) compared to conventional care in elective colorectal surgery.
- - In a randomized controlled trial with 60 patients, those in the ERAS group experienced quicker recovery times, with faster return of bowel sounds (20.63 hours) and first flatus (18.67 hours), compared to conventional care patients (27.0 hours and 25.93 hours, respectively).
- - The mean hospital stay for the ERAS group was significantly shorter at 3.37 days compared
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