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Socioeconomics and attributable etiology of primary liver cancer, 1990-2019. | LitMetric

AI Article Synopsis

  • - Primary liver cancer (PLC) is a significant cause of cancer-related deaths worldwide, highlighting the need for data on its incidence and mortality rates for effective resource allocation by policymakers.
  • - A study using Global Burden of Disease 2019 data found that the burden of PLC varies by country, sex, and socioeconomic development, with hepatitis B being the leading cause in many areas.
  • - Results indicated a decrease in PLC incidence rates from 1990 to 2019, with high and middle socioeconomic regions experiencing the highest rates, reinforcing the link between economic status and health outcomes.

Article Abstract

Background: Primary liver cancer (PLC) is a major contributor to cancer-related deaths. Data on global and country-specific levels and trends of PLC are essential for understanding the effects of this disease and helping policymakers to allocate resources.

Aim: To investigate the association between the burden of PLC and socioeconomic development status.

Methods: Cancer mortality and incidence rates were obtained from the Global Burden of Disease (GBD) 2019, and the data were stratified by country and territory, sex, and the Socio-demographic Index (SDI) level. The association between the attributable etiology of PLC and socioeconomic development status, represented using the SDI, was described. The attributable etiology of PLC included hepatitis B, hepatitis C, alcohol use, and nonalcoholic steatohepatitis. The association between the attributable etiology of PLC and SDI was further stratified by sex and geographical location. A confidence analysis was also performed based on bootstrap draw.

Results: The age-standardized incidence rate of PLC was 6.5 [95% confidence intervals (CI): 5.9-7.2] per 100000 person-years, which decreased by -27.5% (-37.0 to -16.6) from 1990 to 2019. Several countries located in East Asia, South Asia, West Africa, and North Africa shouldered the heaviest burden of PLC in 2019. In terms of incidence rates, the first leading underlying cause of PLC identified was hepatitis B, followed by hepatitis C, alcohol use, and nonalcoholic steatohepatitis. Regarding stratification using the SDI, the incidence rate of PLC was the highest for high and middle SDI locations. Further, the leading attributable etiologies of PLC were hepatitis B for the middle and high middle SDI locations while hepatitis C and nonalcoholic steatohepatitis for the high SDI locations.

Conclusion: The pronounced association between socioeconomic development status and PLC burden indicates socioeconomic development status affects attributable etiologies for PLC. GBD 2019 data are valuable for policymakers implementing PLC cost-effective interventions.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9185214PMC
http://dx.doi.org/10.3748/wjg.v28.i21.2361DOI Listing

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