AI Article Synopsis
- Heart failure, primarily due to the loss or dysfunction of heart muscle cells (cardiomyocytes), is a leading cause of death worldwide, sparking interest in myocardial regeneration techniques for heart repair.
- The field has experienced both advancements and setbacks, with ongoing debates about the heart's regenerative abilities and a mix of successes and failures in translating lab findings to real-world treatments.
- The research delves into existing and promising future regenerative methods, including those still in experimental stages, to provide insight into improving heart failure management and treatment approaches.
Article Abstract
Unlabelled: Heart failure secondary to cardiomyocyte loss and/or dysfunction is the number one killer worldwide. The field of myocardial regeneration with its far-reaching primary goal of cardiac remuscularization and its hard-to-accomplish translation from bench to bedside, has been filled with ups and downs, steps forward and steps backward, controversies galore and, unfortunately, scientific scandals. Despite the present morass in which cardiac remuscularization is stuck in, the search for clinically effective regenerative approaches remains keenly active. Starting with a concise overview of the still highly debated regenerative capacity of the adult mammalian heart, we focus on the main interventions, that have reached or are close to clinical use, critically discussing key findings, successes, and failures. Finally, some promising and innovative approaches for myocardial repair/regeneration still at the pre-clinical stage are discussed to offer a holistic view on the future of myocardial repair/regeneration for the prevention/management of heart failure in the clinical scenario.
Funding: This research was funded by Grants from the Ministry of University and Research PRIN2015 2015ZTT5KB_004; PRIN2017NKB2N4_005; PON-AIM - 1829805-2.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253597 | PMC |
| http://dx.doi.org/10.1016/j.eclinm.2022.101530 | DOI Listing |
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