The feasibility, performance, and radiation safety of an experimental generator were evaluated to efficiently produce Pb intended for radiopharmaceuticals. The generator consisted of a flask with a removable cap containing a source of Ra or Th absorbed on quartz wool. Gaseous Rn emanated from the decaying source, which subsequently decayed to Pb, which was adsorbed on the flask's interior surface. The Pb was collected by washing the flask with 0.5-1 mL of 0.1 M HCl. The generator collector flask trapped 62%-68% of the Pb, of which more than 87% (tested up to 26 MBq) could be harvested. The obtained Pb solution had a high purity (>99.98%) and could be used for the preparation of radioconjugates with more than 97% radiochemical purity. Future designs of the generator should aim to further reduce the risk of radon and γ-energy exposure to operators. The presented technology is a promising method for easy and convenient Pb production.
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| http://dx.doi.org/10.2967/jnumed.122.264009 | DOI Listing |
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