Ethnopharmacological Relevance: Cassia fistula is widely used in traditional Persian Medicine as a mild laxative. The rate of chronic constipation increases above the age of 60.
Aim Of The Study: This study aimed to investigate the effect of Cassia fistula syrup (CFS) on geriatric constipation.
Materials And Methods: This clinical trial study was performed on 70 aged patients who were referred to the clinic of gastroenterology of Rouhani Hospital, Babol, North of Iran. Patients were randomly divided into two groups of CFS or Lactulose with a dose of 30 ccs/day. Patients were visited two weeks after entering the study to evaluate the frequency of defecation, feeling of incomplete emptying after defecation, manual maneuver, consistency of stool, and also the quality of life.
Results: The frequency of defecation per week varied from 1.82 ± 1.16 to 8.36 ± 3.44 in the CFS group after 2 weeks of intervention that was significantly more than the Lactulose that changed from 2.16 ± 1.46 to 5.66 ± 2.96 (P-value = 0.023, partial eta square = 0.079, NNT = 4). The quality of life, the percent of straining, lumpy or hard stool, pain during defecation, and the consistency of stool based on VAS were significantly better in the CFS group. The sensation of incomplete defecation, anorectal obstruction, and manual maneuvering were not different significantly between groups.
Conclusion: CFS can be more effective than Lactulose on geriatric constipation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jep.2022.115466 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Antibacterial Activity of Crude , , and Methanolic Extracts on serovar Manilae.
Acta Med Philipp
December 2024
Department of Biochemistry and Molecular Biology, College of Medicine, University of the Philippines Manila.
Background And Objective: Leptospirosis is a disease caused by pathogenic prevalent in tropical countries like the Philippines. Some studies have shown that the role of currently used antibiotics for leptospirosis is unclear since trials have found no significant benefit to patient outcomes compared to placebo. This signals the need for alternative therapies, such as herbal medicines, which may provide effective therapeutic regimens in treating this infection.
View Article and Find Full Text PDFInsecticidal and Bactericidal Activities of Vahl and Molecular Docking Analysis of Insect Acetylcholinesterase.
Turk J Pharm Sci
January 2025
University of Tlemcen, Faculty of Science, Department of Chemistry, Laboratory of Natural and Bioactive Substances, Tlemcen, Algeria.
Objectives: This study focused on the phytochemical, insecticidal, and bactericidal activities of Vahl, as well as molecular docking analysis of an acetylcholinesterase (AChE) inhibitor as a promising natural insecticide.
Materials And Methods: The leaves of were successively extracted with n-hexane, acetone, and methanol. Silica gel column chromatography of the methanol extract yielded compound 1.
Seasonal Variation in Chemical Composition and Antioxidant and Antibacterial Activity of Essential Oil from Leaves.
Plants (Basel)
December 2024
Guangdong Key Laboratory for Innovative Development and Utilization of Forest Plant Germplasm, South China Agricultural University, Guangzhou 510642, China.
has been extensively utilized in traditional medicine systems worldwide. The essential oil (EO) content and composition are influenced by various external and internal factors, such as climate and harvest season, making it vital to determine the optimal harvest period for high-quality EO production. This study is the first to evaluate the chemical profiles, as well as the antioxidant and antibacterial activities, of leaf oil across the four seasons.
View Article and Find Full Text PDFApplication of Microsponge Drug Platform to Enhance Methotrexate Administration in Rheumatoid Arthritis Therapy.
Pharmaceutics
December 2024
Nanofaber S.r.l., Via Anguillarese 301, 00123 Rome, Italy.
Background/objectives: This study aimed to develop a novel nanotechnological slow-release drug delivery platform based on hyaluronic acid Microsponge (MSP) for the subcutaneous administration of methotrexate (MTX) in the treatment of rheumatoid arthritis (RA). RA is a chronic autoimmune disease characterized by joint inflammation and damage, while MTX is a common disease-modifying antirheumatic drug (DMARD), the conventional use of which is limited by adverse effects and the lack of release control.
Methods: MSP were synthesized as freeze-dried powder to increase their stability and allow for a facile reconstitution prior to administration and precise MTX dosing.
Pharmacological profiling of medicinal plants: a contemporary overview.
Nat Prod Res
January 2025
Institute of Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan.
Throughout history, medicinal plants have played a significant role in various traditional medical systems. This review article focusses on therapeutic properties of , and . These plants have earned recognition for their curative, medical, life-sustaining and chemical uses.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!