Corticostriatal circuits represent value and choice during value-guided decision making. In this issue of Neuron, Balewski et al. (2022) show that caudate nucleus and orbitofrontal cortex use distinct value signals during choice, which are consistent with two parallel valuation mechanisms, one fast, one slow.
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http://dx.doi.org/10.1016/j.neuron.2022.06.011 | DOI Listing |
Sci Robot
January 2025
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
Aerial insects are exceptionally agile and precise owing to their small size and fast neuromotor control. They perform impressive acrobatic maneuvers when evading predators, recovering from wind gust, or landing on moving objects. Flapping-wing propulsion is advantageous for flight agility because it can generate large changes in instantaneous forces and torques.
View Article and Find Full Text PDFSci Robot
January 2025
Sony Computer Science Laboratories Inc. (Sony CSL), Tokyo, Japan.
For trained individuals such as athletes and musicians, learning often plateaus after extensive training, known as the "ceiling effect." One bottleneck to overcome it is having no prior physical experience with the skill to be learned. Here, we challenge this issue by exposing expert pianists to fast and complex finger movements that cannot be performed voluntarily, using a hand exoskeleton robot that can move individual fingers quickly and independently.
View Article and Find Full Text PDFJ Chem Phys
January 2025
Department of Chemistry and Oden Institute for Computational Engineering and Sciences, University of Texas at Austin, Austin, Texas 78712, USA.
Inferring underlying microscopic dynamics from low-dimensional experimental signals is a central problem in physics, chemistry, and biology. As a trade-off between molecular complexity and the low-dimensional nature of experimental data, mesoscopic descriptions such as the Markovian master equation are commonly used. The states in such descriptions usually include multiple microscopic states, and the ensuing coarse-grained dynamics are generally non-Markovian.
View Article and Find Full Text PDFJ Am Chem Soc
January 2025
Department of Polymer Science and Engineering, University of Massachusetts, Amherst, Massachusetts 01003, United States.
Direct translocation of RNA with secondary structures using single-molecule electrophoresis through protein nanopores shows significant fluctuations in the measured ionic current, in contrast to unstructured single-stranded RNA or DNA. We developed a multiscale model combining the oxRNA model for RNA with the 3-dimensional Poisson-Nernst-Planck formalism for electric fields within protein pores, aiming to map RNA conformations to ionic currents as RNA translocates through three protein nanopores: α-hemolysin, CsgG, and MspA. Our findings reveal three distinct stages of translocation (pseudoknot, melting, and molten globule) based on contact maps and current values.
View Article and Find Full Text PDFChem Res Toxicol
January 2025
Collaborations Pharmaceuticals, Inc., 1730 Varsity Drivef, Suite 360, Raleigh, North Carolina 27606-5228, United States.
We have assessed the human liver microsomal (HLM) metabolism of the chemical warfare nerve agents' sarin (GB), cyclosarin (GF), and the Novichok agents A-230 and A-232. In HLM, GB showed drastically decreased stability ( = 1.4 h).
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