Psittacine neuropathic gastric dilatation was studied in four cockatoos (Cacatua spp.). The birds died with characteristic clinical signs, and post-mortem examination revealed a highly distended proventriculus. Upon light microscopic examination, most of the ganglia of the gastric plexus and some of the duodenal myenteric plexus appeared destroyed and replaced by round cell accumulations; the same was true for the celiac ganglion. The neuronal perikaryon of the celiac ganglion and the myenteric plexus revealed intranuclear and extranuclear eosinophilic inclusion bodies. The electron microscope revealed virus-like particles outside and within those inclusions. These particles were similar to particles described and identified as paramyxovirus.
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Phytomedicine
January 2025
Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Changle West Street 15, Xi'an, Shaanxi, 710032, China. Electronic address:
Background: The pathogenesis of neuropathic pain is complex and lacks effective clinical treatment strategies. Medical plants and herbal extracts from traditional Chinese medicine with multi-target comprehensive effects have attracted great attention from scientists.
Purpose: To investigate the pharmacological active components and mechanism underlying the anti-neuralgia effect of classic analgesic formulas Duhuo Jisheng Mixture (DJM).
Metabolites
December 2024
Department of Physiology, College of Korean Medicine, Kyung Hee University, Seoul 02453, Republic of Korea.
Background: Paclitaxel is a widely used anticancer drug for ovarian, lung, breast, and stomach cancers; however, its clinical use is often limited by the side effects of peripheral neuropathy. This study evaluated the effects of () extract and its active metabolite, α-cyperone, on paclitaxel-induced neuropathic pain.
Methods: The oral administration of extract at doses of 500 mg/kg and intraperitoneal administration of α-cyperone at doses of 480 and 800 μg/kg prevented both the development of cold and mechanical pain.
Adv Pharmacol Pharm Sci
December 2024
Laboratory of Animal Physiology and Phytopharmacology, Department of Animal Biology, Faculty of Science, University of Dschang, Dschang, Cameroon.
Linn. (, Vitaceae) is a plant reported to treat injured tendons, broken bones, asthma, stomach ache, scurvy, and digestive disorders. The present study evaluated the antihyperalgesic effects of ethanolic extract of Linn.
View Article and Find Full Text PDFJ Plast Reconstr Aesthet Surg
November 2024
The Breast Unit, The Wellington Hospital, HCA Healthcare UK, London, UK.
Introduction: Silicone breast implants are widely prevalent. An increasing group of patients detail self-reported somatic and psychological symptoms that have been ascribed as breast implant illness (BII) and seek capsulectomy and implant removal. To guide consultations and shared decision making, more outcome data relating to this intervention are required.
View Article and Find Full Text PDFNeurogastroenterol Motil
October 2024
Department of Gastroenterology and Hepatology, Maastricht University Medical Center, Maastricht, the Netherlands.
Background: Gastric peroral endoscopic pyloromyotomy (G-POEM) is a promising therapeutic modality for refractory gastroparesis (GP). However, as characteristics of suitable patients for G-POEM remain unclear, antro-duodenal manometry (ADM) has been suggested to provide objective parameters for patient selection. The aim of the present study was to identify ADM parameters as predictors for treatment response after G-POEM in refractory GP.
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