AI Article Synopsis
- Oligoclonal bands indicate the presence of disease-specific antibodies resulting from B lymphocyte activation, often seen in conditions like multiple sclerosis and SSPE.
- The report details a case of a 15-year-old male with SSPE, exhibiting myoclonic jerks and positive anti-measles IgG tests, suggesting prior measles exposure.
- This study highlights the significance of oligoclonal bands in diagnosing SSPE, a neurodegenerative disease caused by persistent measles virus infection in the brain.
Article Abstract
The oligoclonal band indicates presence of antibodies specific to the disease, possibly due to the activation of certain clones of B lymphocytes. This intrathecal immunoglobin synthesis can be persistent for months to years, for example, in respons to paramyxoviruses, herpes virus, coxsackievirus, and Treponema pallidum; or can be synthesized for life, for example in multiple sclerosis and subacute sclerosing panencephalitis (SSPE). We report a case of SSPE in a 15-year-old male patient. The patient had myoclonic jerks that occurred in the thoracal femoral region. Necessary laboratory tests identified reactive anti-measles IgG, which indicates a previous measles infection or exposure to vaccination. This report describes the usefulness of the oligoclonal bands in the diagnosis of the neurodegenerative disease SSPE that is progressive and fatal to the central nervous system due to persistent measles virus infection in the gray and white matter.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3855/jidc.15200 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!