AI Article Synopsis
- The study aimed to examine how tamoxifen affects tooth loss in women who have survived breast cancer, using a sample of 140 participants and assessing various sociodemographic and dental factors.
- Results indicated that breast cancer survivors on tamoxifen for over a year experienced significantly increased tooth loss, with a mean of 12.96 missing teeth, and factors like age and dental care usage also contributed to this issue.
- The conclusion highlighted that prolonged tamoxifen use correlates with greater tooth loss, suggesting a need for enhanced oral health care strategies for breast cancer survivors undergoing this treatment.
Article Abstract
Objectives: Investigate the effect of tamoxifen on the occurrence of tooth loss (TL) in breast cancer (BC) survivors.
Methods: A cross-sectional study was conducted with 140 BC survivors using tamoxifen therapy. Sociodemographic, medical, and dental data were evaluated. TL was determined using the M component of the Decayed, Missing and Filled Teeth (DMFT) index. Logistic regression models were run to determine associations between the independent variables and outcome (TL).
Results: Mean TL was 12.96 (SD 8.88). Only three participants had lost no teeth and 10.7% were completely edentulous. Participants who used tamoxifen for more than 1 year had a higher mean missing teeth (13.99 vs. 10.45; P = 0.030). After the adjustments, the occurrence of more than 12 missing teeth was 2.75-fold higher among women who used tamoxifen for more than 1 year (95% CI: 1.06-7.12). Moreover, age over 65 years, referral for treatment by the public healthcare system, less use of dental services, xerostomia, and a lower occurrence of dental caries remained associated with the loss of more than 12 teeth.
Conclusion: Longer use of tamoxifen was associated with greater tooth loss in breast cancer survivors.
Clinical Relevance: Based on estimates of the increase in cases of breast cancer, the prolonged use of tamoxifen for the treatment of this disease can exert an impact on oral health through the occurrence of tooth loss. These findings can contribute to the planning and implementation of oral health care and prevention strategies for such patients.
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| http://dx.doi.org/10.1007/s00520-022-07271-4 | DOI Listing |
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