Mistakes strengthen the temporal binding effect in the context of goal-directed actions.

Exp Brain Res

Social Brain, Body and Action Lab, Department of Psychology, Neuroscience and Behaviour, McMaster University, Psychology Building (PC), Room 102, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada.

Published: August 2022

Temporal binding is an illusion in which the temporal interval between two events appears compressed. In the context of intentional actions, this effect is observed as a compression of the perceived interval between these actions and their causal outcomes. This 'intentional binding effect' has been used to investigate the Sense of Agency, which is the experience of intentionally causing an outcome through volitional action. Intentional binding is reduced for negative outcomes such as error feedback, but the role of mistakes (e.g., errors of commission) for binding and agency has not been extensively studied. In our study, participants played a virtual game in which they attempted to 'splat' (hit) visual stimuli that looked like coloured bugs, using mouse clicks. On some trials, stimulus colours changed unpredictably immediately before actions were made, sometimes inducing mistakes. Actions were thus clearly identifiable as mistakes at the time of their onset before any outcome feedback had been provided. Participants reported shorter action-outcome intervals when stimuli changed, but only when this change caused a mistake according to the game's rules. This suggests that intentional binding is strengthened by errors of commission. We discuss how this effect may be accounted for by agency itself and via more general processes such as changes in arousal.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00221-022-06407-6DOI Listing

Publication Analysis

Top Keywords

temporal binding
8
intentional binding
8
errors commission
8
binding
6
actions
5
mistakes
4
mistakes strengthen
4
strengthen temporal
4
binding context
4
context goal-directed
4

Similar Publications

Approximately 40% of individuals undergoing anterior temporal lobe resection for temporal lobe epilepsy experience episodic memory decline. There has been a focus on early memory network changes; longer-term plasticity and its impact on memory function are unclear. Our study investigates neural mechanisms of memory recovery and network plasticity over nearly a decade post-surgery.

View Article and Find Full Text PDF

Background: Postprandial hyperglycemia induces expression of inflammatory cytokines including tumor necrosis factor (TNF), which promotes the onset of type 2 diabetes and cardiovascular diseases. In this study, we investigated whether a transient high-glucose culture enhanced sustained expression of TNF, or whether the induction is associated with histone acetylation, and bromodomain protein containing protein 4 (BRD4), which binds acetylated histone, in human juvenile macrophage-like THP-1 cells.

Methods: THP-1 cells were cultured in medium with high-glucose in the presence or absence of (+)-JQ1, an inhibitor of bromodomain and extra-terminal domain family, for 24 h (day 0).

View Article and Find Full Text PDF

Single-molecule imaging for investigating the transcriptional control.

Mol Cells

January 2025

Department of Regulatory Science, Graduate School, Kyung Hee University, Seoul 02447, Korea; College of Pharmacy, Kyung Hee University, Seoul 02447, Korea; Institute of Regulatory Innovation through Science (IRIS), Kyung Hee University, Seoul 02447, Korea. Electronic address:

Transcription is an essential biological process involving numerous factors, including transcription factors (TFs) which play a central role in this process by binding to their cognate DNA motifs. Although cells must tightly regulate the kinetics of factor association and dissociation during transcription, factor dynamics during transcription remain poorly characterized, primarily because of the reliance on ensemble experiments that average out molecular heterogeneity. Recent advances in single-molecule fluorescence imaging techniques have enabled the exploration of TF dynamics at unprecedented resolution.

View Article and Find Full Text PDF

Spo0A in Bacillus subtilis is activated by phosphorylation (Spo0A~P) upon starvation and differentially controls a set of genes involved in biofilm formation and sporulation. The spo0A gene is transcribed by two distinct promoters, a σ-recognized upstream promoter Pv during growth, and a σ-recognized downstream promoter Ps during starvation, and appears to be autoregulated by four Spo0A~P binding sites (0A1-4 boxes) localized between two promoters. However, the autoregulatory mechanisms and their impact on differentiation remain elusive.

View Article and Find Full Text PDF

The degeneration of pyramidal tracts has been reported in frontotemporal lobar degeneration with TDP-43 (TAR DNA-binding protein 43) pathology (FTLD-TDP) type C. Herein, we examined the detailed pathology of the primary motor area and pyramidal tracts in the central nervous system in four autopsy cases of FTLD-TDP type C, all of which were diagnosed by neuropathological, biochemical, and genomic analyses. Three patients showed right dominant atrophy of the frontal and temporal lobes, while the other patient showed left dominant atrophy.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!