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Multiphasic Computed Tomography Enhancement Characteristics and Utility of Delayed Phase in Infiltrative Hepatocellular Carcinoma.
Indian J Radiol Imaging
January 2025
Department of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
The aims of this study are to compare the multiphasic contrast-enhanced computed tomography (CECT) characteristics of infiltrative hepatocellular carcinoma (HCC) with nodular HCC and to assess the conspicuity of infiltrative HCC on different phases of CECT. This retrospective study comprised consecutive treatment-naive cirrhotic patients diagnosed with infiltrative and nodular HCC between January 2020 and December 2021 based on a multiphasic CECT (comprising arterial, portal venous, and delayed phases). The diagnosis of HCC was based on the Liver Imaging Reporting and Data System (LI-RADS) v2018 criteria (LR-4 and LR-5 lesions).
View Article and Find Full Text PDFValidation Study of the Newly Proposed Refined Diagnostic Criteria for Malignant Phyllodes Tumor With 136 Borderline and Malignant Phyllodes Tumor Cases.
Am J Surg Pathol
September 2024
Department of Pathology, Northwestern University, Evanston, IL.
The World Health Organization (WHO) diagnostic criteria for malignant phyllodes tumor (MPT) may miss a significant number of MPTs with metastatic potential. New refined diagnostic criteria (Refined Criteria) for MPT were recently proposed. The aim of this study is to validate the Refined Criteria.
View Article and Find Full Text PDFChondrosarcoma of the maxilla.
BMJ Case Rep
November 2023
ENT, Lokmanya Tilak Municipal Medical College and General Hospital, Mumbai, Maharashtra, India.
A woman in her 70s reported to the outpatient department of our tertiary care hospital with chief complaints of painless swelling in the right cheek and palatal area. The patient was a known case of diabetes mellitus and hypertension on medications with controlled sugars and blood pressure. The swelling was 10×8 cm in size extending from right infraorbital region up to the lower mandible.
View Article and Find Full Text PDFComprehensive Clinical-Pathologic Assessment of Malignant Phyllodes Tumors: Proposing Refined Diagnostic Criteria.
Am J Surg Pathol
November 2023
Department of Pathology and Laboratory Medicine, Emory University Hospital, Atlanta, GA, USA.
Article Synopsis
- The World Health Organization's latest criteria for diagnosing malignant phyllodes tumors (MPTs) require the presence of five specific morphologic features, but this study found that only 20% of cases met all criteria.
- In a review of 65 MPT cases, common features included permeative borders and stromal overgrowth, but only a small percentage of tumors with distant metastases had all five features.
- Researchers propose new diagnostic criteria that combine stromal overgrowth or marked cellularity with other key features to better identify MPTs and predict their potential for metastasis.
NTRK Fusion in a Cohort of BRAF p. V600E Wild-Type Papillary Thyroid Carcinomas.
Mod Pathol
August 2023
Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. Electronic address:
Owing to the availability of a potent tropomyosin receptor kinase (TRK) inhibitor, it is necessary to develop an effective strategy to identify an enriched population of NTRK fusions in papillary thyroid carcinoma (PTC) in routine diagnostic practice. The reported prevalence of NTRK fusion in a large cohort of PTC is ∼3%. We performed an analysis to refine the characteristic histologic features of PTCs harboring NTRK fusions and further validate the diagnostic utility of pan-TRK immunohistochemistry as a screening tool.
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