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[Plastic surgical treatment of neurofibromatosis type 1].
Chirurgie (Heidelb)
January 2025
Universitätsklinik für Plastische, Rekonstruktive und Ästhetische Chirurgie, Medizinische Universität Wien, Wien, Österreich.
Neurofibromatosis type 1 (NF1, formerly Recklinghausen's disease) is a genetic tumor predisposition syndrome in which the mutation of a tumor suppressor gene (neurofibromin) leads to the development of mostly benign neurofibromas of the skin and the central and peripheral nervous systems and malformations or tumors of other organ systems. Patients with NF1 should receive lifelong interdisciplinary care in specialized centers and important treatment decisions should be made by a regularly meeting interdisciplinary panel of experts. Plastic surgery plays an important role in the multidisciplinary management of all clinical forms of NF1-associated peripheral nerve sheath tumors, from cutaneous and subcutaneous to deep nodular and diffuse plexiform neurofibromas.
View Article and Find Full Text PDFA novel clinical investigation using deep learning and human-in-the-loop approach in orbital volume measurement.
J Craniomaxillofac Surg
January 2025
Department of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University, Daegu, Republic of Korea. Electronic address:
Orbital volume assessment is crucial for surgical planning. Traditional methods lack efficiency and accuracy. Recent studies explore AI-driven techniques, but research on their clinical effectiveness is limited.
View Article and Find Full Text PDFEarly osteopathic manipulative treatment to prevent cranial positional deformities: A randomized controlled trial.
Arch Pediatr
January 2025
Pediatric Orthopedic and Plastic Surgery, University of Montpellier, Montpellier University Hospital, Montpellier, France; Centre de Compétence Maladies Rares CRANIOST, University of Montpellier, Montpellier University Hospital, Montpellier, France. Electronic address:
Background: Cranial positional deformities occur frequently in the first months of life.
Objective: To evaluate the effectiveness of osteopathic manipulative treatment (OMT) in preventing the onset of positional plagiocephaly and brachycephaly at 4 months in at-risk newborns.
Methods: This single-center, randomized, controlled open-label study, with blinded assessment of the endpoints, was carried out at the maternity unit of Montpellier University Hospital (France) between 2019 and 2022.
Applying the Modified Five-Item Frailty Index to Predict Complications following Lower Extremity Free Flap Reconstruction in Trauma Patients.
J Reconstr Microsurg
January 2025
Section of Plastic and Reconstructive Surgery, Department of Surgery, University of Chicago Medicine, Chicago, Illinois.
Background: Free flap reconstruction in the setting of lower extremity trauma continues to be a challenging clinical problem fraught with a high risk of complications including flap compromise. Although studies have described certain risk factors that predispose these patients to poor outcomes, there remains a paucity of literature detailing frailty as a risk factor. As such, the aim of our study was to examine the application of the 5-item modified frailty index (mFI-5) in trauma patients undergoing lower extremity free flap reconstruction.
View Article and Find Full Text PDFEffects of omega-3 polyunsaturated fatty acids on inflammation resolution and angiogenesis in fat grafts in a controlled mouse model.
Plast Reconstr Surg
January 2025
All from the Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shijingshan District, Beijing, China.
Background: The upregulation or delay of acute inflammation at any stage limits fat graft survival. Active endogenous inflammation resolution mechanisms and mediators are novel therapeutic tools for inflammation. This study explored the effects of supplementation of omega-3 polyunsaturated fatty acids (PUFAs) deriving specialized proresolving mediators (SPMs) on postoperative inflammation and graft survival in vivo.
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