AI Article Synopsis
- - The text discusses how lifespan is influenced by complex mechanisms, with a focus on the early postnatal period and the potential impact of a short rapamycin treatment on lifespan in mice and fruit flies.
- - Results indicate that administering rapamycin early in life can extend lifespan, while the same treatment later on does not have this effect, highlighting a critical time window for lifespan regulation.
- - The study also reveals that early rapamycin treatment increases the levels of sulfotransferases in both newborn mice and fly larvae, and boosting specific gene expression in fruit flies can lead to a longer lifespan.
Article Abstract
Lifespan is determined by complex and tangled mechanisms that are largely unknown. The early postnatal stage has been proposed to play a role in lifespan, but its contribution is still controversial. Here, we show that a short rapamycin treatment during early life can prolong lifespan in Mus musculus and Drosophila melanogaster. Notably, the same treatment at later time points has no effect on lifespan, suggesting that a specific time window is involved in lifespan regulation. We also find that sulfotransferases are upregulated during early rapamycin treatment both in newborn mice and in Drosophila larvae, and transient dST1 overexpression in Drosophila larvae extends lifespan. Our findings unveil a novel link between early-life treatments and long-term effects on lifespan.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9442325 | PMC |
| http://dx.doi.org/10.15252/embr.202255299 | DOI Listing |
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