Digitalization brings challenges and new opportunities to the development of landscape gardening, "smart gardening," which is a product of landscape gardening in response to the development of the digital era. Based on the multimodal intelligent computing method and deep neural network machine learning algorithm, this paper adopts "digital landscape design logic" to analyze and research smart gardens and digital design. The digital landscape design process and methods are discussed based on design logic, design basis, environment analysis, and results presentation, and the greenery maintenance scheduling system is constructed. The paper focuses on the digital implementation of the environmental analysis of the site and uses Rhino software and Grasshopper visual programming language to build parametric logic, establish parametric analysis models, and conduct a comprehensive analysis of the current environment. The main theme of the whole paper is a logical approach to digital landscape design for smart gardens, using digital technology tools from the perspective of smart garden thinking, combining quantitative analysis and qualitative design, and intervening in digital landscape garden planning and design to explore the application of digital technology and tools.
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http://dx.doi.org/10.1155/2022/8307398 | DOI Listing |
Nature
January 2025
Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu, China.
Identifying phase-separated structures remains challenging, and effective intervention methods are currently lacking. Here we screened for phase-separated proteins in breast tumour cells and identified forkhead (FKH) box protein M1 (FOXM1) as the most prominent candidate. Oncogenic FOXM1 underwent liquid-liquid phase separation (LLPS) with FKH consensus DNA element, and compartmentalized the transcription apparatus in the nucleus, thereby sustaining chromatin accessibility and super-enhancer landscapes crucial for tumour metastatic outgrowth.
View Article and Find Full Text PDFAnn Surg Oncol
January 2025
Division of Surgery, Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Pancreatic cancer has a poor prognosis despite ongoing advances in systemic and multimodal therapies. This review analyzes recent progress and future directions in pancreatic cancer clinical trials, emphasizing the evolution from traditional approaches to a more personalized and biologically-driven treatment paradigm. While improvements in overall survival have been achieved through perioperative therapies, gaps remain in our understanding of optimal treatment strategies.
View Article and Find Full Text PDFNat Struct Mol Biol
January 2025
Helmholtz Institute for RNA-based Infection Research, Helmholtz Centre for Infection Research (HIRI-HZI), Würzburg, Germany.
Human immunodeficiency virus-1 (HIV-1) uses a number of strategies to modulate viral and host gene expression during its life cycle. To characterize the transcriptional and translational landscape of HIV-1 infected cells, we used a combination of ribosome profiling, disome sequencing and RNA sequencing. We show that HIV-1 messenger RNAs are efficiently translated at all stages of infection, despite evidence for a substantial decrease in the translational efficiency of host genes that are implicated in host cell translation.
View Article and Find Full Text PDFCurr Opin Urol
January 2025
Department of Urology, New York University, New York, New York, USA.
Purpose Of Review: We reviewed the latest articles in patient-reported outcomes as it relates to genital gender-affirming surgery (GGAS) and provide a narrative summary of each article.
Recent Findings: The current landscape of patient-reported outcomes measures (PROMs) within GGAS largely consists of various ad hoc questionnaires. Within the last two years, one new PROM, validated within the transgender and gender-diverse (TGD) community, have been described.
BMC Prim Care
January 2025
Centre for Psychiatry and Mental Health, Wolfson Institute of Population Health, QMUL, London, UK.
Objective: As populations age globally, there is increasing prevalence of multiple long-term conditions, such as dementia, leading to many challenges. The burden on health and care services, economic pressures, and the necessity for innovative policies to better support older people and people with dementia becomes paramount. This review explores how clinical pharmacists working in UK primary care support older people and people with dementia.
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