Humor and the surgeon.

Arch Surg

Published: May 1987

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http://dx.doi.org/10.1001/archsurg.1987.01400170025002DOI Listing

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Schlemm's canal (SC) is a small circular canal in the deep part of the sclera at the junction of the sclera and cornea. As an integral component of the aqueous humor outflow, its structure and function are essential in regulating intraocular pressure (IOP). If SC develops lesions, the drainage of aqueous humor would be obstructed, leading to increased intraocular pressure and injury to the optic nerve.

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Glaucoma is a disease that leads to optic nerve damage and irreversible loss of the visual field. Gonioscopy-assisted transluminal trabeculotomy (GATT) is a minimally invasive glaucoma surgery technique, where the surgeon opens the trabecular network and Schlemm's canal to improve the outflow of the aqueous humor. This method has shown efficacy in reducing intraocular pressure in patients with primary and secondary glaucoma.

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Using Electronic Health Record Data to Determine the Safety of Aqueous Humor Liquid Biopsies for Molecular Analyses.

Ophthalmol Sci

March 2024

Department of Ophthalmology, Spencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, California.

Article Synopsis
  • The study aims to assess the surgical safety of anterior chamber liquid biopsies in order to promote the use of proteomics and molecular analyses for understanding diseases in patients and clinical trials.
  • It involved a retrospective case series of 1418 aqueous humor biopsies, using the Stanford Research Repository tool to identify complications related to the procedures and ensure efficient data review.
  • Results showed that the free-text searches had very high accuracy for identifying surgical complications, with only one minor complication occurring (0.07%) and a follow-up period of over 7 months.
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Significance: Monitoring blood glucose levels is crucial for individuals with diabetes. Noninvasive methods for measuring serum glucose levels have been explored to aid in blood glucose control for diabetes management.

Aim: We introduced a noncontact optical glucometer (NCGM) for measuring glucose levels in the aqueous humor of the human eye.

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Aqueous humor outflow (AHO) pathways are the main site of resistance causing elevated intraocular pressure in glaucoma, especially primary open-angle glaucoma patients. With the recently introduced technique of aqueous angiography (AA); functional, real time assessment of AHO from proximal (trabecuar meshwork) to distal pathways under physiological conditions has been made possible. AHO pathways are segmental, and AA can identify high-flow region (increased angiographic signals) and low flow region (decreased angiographic signals) in an individual.

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