AI Article Synopsis
- The prognosis for patients with unresectable adrenocortical carcinoma is generally poor, with mitotane as the primary treatment and combination chemotherapy recommended for resistant cases.
- A 49-year-old woman with advanced disease experienced progression on mitotane, but showed significant improvement and complete disappearance of liver metastases after 9 months of chemotherapy using paclitaxel and carboplatin alongside mitotane.
- This case highlights the potential for long-term survival in advanced adrenocortical carcinoma through effective treatment combining chemotherapy and mitotane, as the patient has thrived for 20 years post-diagnosis.
Article Abstract
Introduction: The prognosis of patients with unresectable adrenocortical carcinoma is poor. Mitotane is the first-line treatment for this disease, and etoposide/doxorubicin/cisplatin/mitotane therapy is recommended as first-line chemotherapy in unresponsive cases. We present a case of long-term survival following combination chemotherapy with paclitaxel and carboplatin plus mitotane to manage mitotane-refractory advanced adrenocortical carcinoma.
Case Presentation: A 49-year-old woman with a left adrenal tumor, lymph node metastasis around the aorta, and multiple liver metastases was treated with mitotane. The disease progressed despite mitotane therapy; thus, combination chemotherapy with paclitaxel and carboplatin plus mitotane was administered for 9 months. Primary adrenal resection was performed after the liver metastasis had completely dissapeared. She has remained alive for 20 years since her initial diagnosis while undergoing mitotane therapy.
Conclusion: In this case, combination chemotherapy with paclitaxel and carboplatin plus mitotane effectively controlled advanced adrenocortical carcinoma.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249639 | PMC |
| http://dx.doi.org/10.1002/iju5.12458 | DOI Listing |
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