AI Article Synopsis
- Many patients with primary vitreoretinal lymphoma (PVRL) often show symptoms related to the central nervous system (CNS) either at diagnosis or later on.
- The prognosis is generally very poor for those with recurrent or hard-to-treat CNS involvement.
- However, a case is reported where a patient with refractory PVRL had a notable but temporary response to tirabrutinib after already undergoing standard treatments, indicating potential benefits of this new targeted therapy.
Article Abstract
Many patients with primary vitreoretinal lymphoma (PVRL) exhibit central nervous system (CNS) involvement either at the diagnosis or during follow-up. The prognosis in the patients of PVRL with relapsed or refractory CNS remains extremely poor. We herein report a patient with refractory PVRL who had recurrence in the spinal cord despite receiving high-dose methotrexate-based chemotherapy and whole-brain radiotherapy. The patient surprisingly responded to tirabrutinib temporarily. We believe that this case suggests the utility of this new target therapy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970806 | PMC |
| http://dx.doi.org/10.2169/internalmedicine.9591-22 | DOI Listing |
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