This paper reviews the application of "co-regulation of body and mind" of acupuncture for post-stroke spasticity. It is found that acupoints on the head and the back of the governor vessel, as well as Jiaji (Ex-B 2) points are mainly used for regulating the mind, and the local sites of spastic muscles and the points on the antagonistic muscles are for regulating the body specially. It is believed that regulating the mind should be integrated with regulating the body, while, the acupoint selection be associated with needling methods so as to fully achieve the "co-regulation of body and mind" and enhance the practical value of acupuncture for post-stroke spasticity. It is proposed that the classical anti-spastic needling techniques, such as (relaxing needling) and (joint needling), should be more considered.
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http://dx.doi.org/10.13703/j.0255-2930.20210718-k0003 | DOI Listing |
Nucleic Acids Res
December 2024
Biology Department, Boston University, 24 Cummington Ave., Boston, 02215, USA.
Exons within transcripts are traditionally classified as first, internal or last exons, each governed by different regulatory mechanisms. We recently described the widespread usage of 'hybrid' exons that serve as terminal or internal exons in different transcripts. Here, we employ an interpretable deep learning pipeline to dissect the sequence features governing the co-regulation of transcription initiation and splicing in hybrid exons.
View Article and Find Full Text PDFBMC Microbiol
November 2024
Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Integrative Microbiology Research Centre, South China Agricultural University, Guangzhou, China.
Background: Pseudomonas aeruginosa is able to survive, grow, and cause severe infections at different sites throughout the human body owing to its ability to sense diverse signals and precisely modulate target gene expression using its abundant signaling systems. Release of zinc (Zn) and hydrogen peroxide (HO) within the phagocyte are two major host strategies to defend against bacterial infections. It was previously shown that the response regulator CzcR controls global gene expression including catalase genes during Zn excess, but regulatory mechanisms of catalase gene expression and the role of CzcR in HO tolerance remain unclear.
View Article and Find Full Text PDFbioRxiv
September 2024
Department of Molecular Pathobiology, College of Dentistry, New York University, New York, NY, USA.
Animals (Basel)
April 2024
Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation, College of Animal & Veterinary Sciences, Southwest Minzu University, Chengdu 610041, China.
Elife
May 2024
Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, United States.
PARP-1 is central to transcriptional regulation under both normal and stress conditions, with the governing mechanisms yet to be fully understood. Our biochemical and ChIP-seq-based analyses showed that PARP-1 binds specifically to active histone marks, particularly H4K20me1. We found that H4K20me1 plays a critical role in facilitating PARP-1 binding and the regulation of PARP-1-dependent loci during both development and heat shock stress.
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