This case report discusses an uncommon presentation of vitamin D intoxication and severe hypercalcaemia attributed to misuse of multiple nutritional supplements (˃20 active agents). A review of this case, supported by accumulated literature, lends room to further public health safety discussions. The multisystemic clinical manifestations of vitamin D toxicity can be debilitating, hence the need to prevent its occurrence.
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http://dx.doi.org/10.1136/bcr-2022-250553 | DOI Listing |
Cureus
December 2024
Department of Internal Medicine IV, Hospital Professor Doutor Fernando Fonseca, Amadora, PRT.
Vitamin K is essential to produce functional vitamin K-dependent coagulation factors (prothrombin, factors VII, IX, and X). Vitamin K antagonists inhibit the normal activation of these factors, leading to bleeding manifestations of variable severity. Long-acting vitamin K antagonists or superwarfarins were developed as rodenticides and have a significantly longer half-life and greater potency when compared to warfarin.
View Article and Find Full Text PDFJCEM Case Rep
January 2025
Department of Medical Oncology, Dr. Jeyasekharan Medical Trust Hospital & Nursing Home, Nagercoil, Tamilnadu 629003, India.
Hypercalcemia of malignancy (HCM) is the most common cause of hypercalcemia in hospitalized patients. The pathogenesis of HCM is often multifactorial. One of the rare causes of HCM is extra-renal production of 1,25-dihydroxyvitamin D (or calcitriol), which is often seen in patients with lymphoproliferative malignancies.
View Article and Find Full Text PDFSci Rep
January 2025
Czech Agrifood Research Center, Drnovska 507/73, CZ-16100, Prague 6, Czech Republic.
Despite the widespread use of anticoagulant rodenticides in baits for controlling commensal rodent pests, their application is problematic due to secondary intoxication and increasing resistance. In contrast to studies on Western European house mice (Mus musculus domesticus), few resistance studies have focused on Eastern European house mice (M. musculus musculus), which have a western distribution boundary in the Czech Republic.
View Article and Find Full Text PDFZh Nevrol Psikhiatr Im S S Korsakova
December 2024
Research Center of Neurology, Moscow, Russia.
Nitrous oxide (NO) intoxication is a common consequence of its inhalation with recreational purpose, which is prevalent among young people. The most severe result of such an entertainment is development of myelopolyneuropathy with polyneuropathy as the most common presentation, which may start acutely or subacutely. The underlying cause of neurological complications of NO intoxication is deficit of B vitamin, however its laboratory confirmation may be challenging.
View Article and Find Full Text PDFCell Mol Biol (Noisy-le-grand)
November 2024
Biology Department, College of Education for Pure Sciences, University of Anbar, Iraq.
This study aimed to evaluate the therapeutic effects of B6 in rats experimentally intoxicated by benzopyrene. Twenty-eight Male Sprague Dawley (white Swiss) rats weighing 170-210 g and 3-4 months old were utilized in this examination. Rats were divided into 4 control groups (G1), B[a]P 2 pmol/μL (G2), B6 only once per 2 days for a full month at 1000 mcg (15 dose per month) (G3), B6 + B[a]P (G4).
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