Photoacoustic imaging for microcirculation.

Microcirculation

Department of Biomedical Engineering, Pennsylvania State University, University Park, Pennsylvania, USA.

Published: October 2022

AI Article Synopsis

  • Microcirculation is crucial for nutrient exchange and tissue health, and its dysfunction may indicate cardiovascular and metabolic issues, making quantitative analysis important for clinical diagnostics.
  • Photoacoustic imaging (PAI) uses light absorption to create high-resolution images of microvasculature, utilizing hemoglobin's properties to generate signals related to blood dynamics such as hemoglobin concentration and oxygen levels.
  • The paper reviews PAI's current capabilities in various medical fields, addresses challenges faced in the technology, and discusses future trends to improve its application in microcirculation imaging.

Article Abstract

Microcirculation facilitates the blood-tissue exchange of nutrients and regulates blood perfusion. It is, therefore, essential in maintaining tissue health. Aberrations in microcirculation are potentially indicative of underlying cardiovascular and metabolic pathologies. Thus, quantitative information about it is of great clinical relevance. Photoacoustic imaging (PAI) is a capable technique that relies on the generation of imaging contrast via the absorption of light and can image at micron-scale resolution. PAI is especially desirable to map microvasculature as hemoglobin strongly absorbs light and can generate a photoacoustic signal. This paper reviews the current state of the art for imaging microvascular networks using photoacoustic imaging. We further describe how quantitative information about blood dynamics such as the total hemoglobin concentration, oxygen saturation, and blood flow rate is obtained using PAI. We also discuss its importance in understanding key pathophysiological processes in neurovascular, cardiovascular, ophthalmic, and cancer research fields. We then discuss the current challenges and limitations of PAI and the approaches that can help overcome these limitations. Finally, we provide the reader with an overview of future trends in the field of PAI for imaging microcirculation.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870710PMC
http://dx.doi.org/10.1111/micc.12776DOI Listing

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