Microcirculation facilitates the blood-tissue exchange of nutrients and regulates blood perfusion. It is, therefore, essential in maintaining tissue health. Aberrations in microcirculation are potentially indicative of underlying cardiovascular and metabolic pathologies. Thus, quantitative information about it is of great clinical relevance. Photoacoustic imaging (PAI) is a capable technique that relies on the generation of imaging contrast via the absorption of light and can image at micron-scale resolution. PAI is especially desirable to map microvasculature as hemoglobin strongly absorbs light and can generate a photoacoustic signal. This paper reviews the current state of the art for imaging microvascular networks using photoacoustic imaging. We further describe how quantitative information about blood dynamics such as the total hemoglobin concentration, oxygen saturation, and blood flow rate is obtained using PAI. We also discuss its importance in understanding key pathophysiological processes in neurovascular, cardiovascular, ophthalmic, and cancer research fields. We then discuss the current challenges and limitations of PAI and the approaches that can help overcome these limitations. Finally, we provide the reader with an overview of future trends in the field of PAI for imaging microcirculation.
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http://dx.doi.org/10.1111/micc.12776 | DOI Listing |
Chem Asian J
January 2025
Rheinisch-Westfalische Technische Hochschule Aachen, Organic Chemistry, Landoltw, 52074, Aachen, GERMANY.
Highly reactive oxygen and nitrogen species (ROS/RNS) play crucial roles in various pathological conditions. Among them, hypochlorous ion (OCl⁻), a potent ROS, is associated in numerous oxidative stress-related disorders. Elevated levels of OCl⁻ are thus recognized as a biomarker for diagnosing inflammatory conditions.
View Article and Find Full Text PDFJ Med Chem
January 2025
Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen 518055, China.
Endowing cyanine dyes with hydrophilicity, long blood circulation, tumor targeting, and robust therapeutic efficacy in the second near-infrared (NIR-II) window is challenging for cancer treatment. Herein, we develop cancer cell membrane-coated albumin-NIR-II cyanine dye assemblies, denoted as LZ-1105@HAm, to optimize the photophysical properties of cyanine dyes in aqueous solution for NIR-II fluorescence (FL)/photoacoustic (PA)/photothermal (PT) multimodality imaging-guided tumor homologous targeting photothermal therapy. LZ-1105@HAm exhibits good hydrophilicity, extends the half-life of blood circulation from 0.
View Article and Find Full Text PDFAdv Healthc Mater
January 2025
Department of Physical Sciences, Indian Institute of Science Education and Research Mohali, Knowledge City, Sector 81, SAS Nagar, Manauli, 140306, India.
Fluoropolymer alone, as an alternative to lead-based piezoelectric materials, has shown multiple challenges to develop useful sensors for solving real-world problems such as photoacoustic, ultrasound pulse echo, and other non-destructive testing. This work demonstrates the fabrication of high frequency and wide bandwidth transducers with fluoropolymer and highly polarizing cubic single crystal Barium titanate (BaTiO) ceramic composite for high resolution in-vivo photo-acoustic and ultrasound imaging. For transducer fabrication, a customized bio-compatible nanocomposite sensor film of PVDF-TrFE (Polyvinylidene fluoride trifluoroethylene)/BaTiO (BTO) is synthesized by drop and dry in heating-cum-electro-poling system for advancing polarization, crystallinity, and higher charge generation.
View Article and Find Full Text PDFPhotoacoustic microscopy has demonstrated outstanding performance in high-resolution functional imaging. However, in the process of photoacoustic imaging, the photoacoustic signals will be polluted by inevitable background noise. Besides, the image quality is compromised due to the biosafety limitation of the laser.
View Article and Find Full Text PDFJ Colloid Interface Sci
January 2025
The Department of Medical Imaging, Guangzhou Key Laboratory of Molecular Functional Imaging and Artificial Intelligence for Major Brain Diseases, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Jinan University, Guangzhou 518037 China. Electronic address:
Microwave dynamic therapy (MWDT) destroy tumor cells using reactive oxygen species (ROS), but its effectiveness is limited by low ROS production and intracellular oxygen (O) availability. This study presents a novel strategy using manganese (II) ion (Mn) doped iron (Fe)-based metal-organic framework (Fe MOF) nanoparticles (NPs) to enhance both O generation and ROS production for improved MWDT. Incorporating Mn into Fe MOF narrows the bandgap from 0.
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