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Comparative efficacy, safety, and oncological outcomes of percutaneous thermal and chemical ablation modalities for recurrent metastatic cervical lymphadenopathy from thyroid cancer.
Surg Oncol
December 2024
Department of Surgery, School of Medicine, Tulane University, New Orleans, LA, 70112, USA. Electronic address:
Background: Thermal and chemical ablation techniques may consolidate recurrent metastatic cervical lymph nodes as alternatives to repeat neck dissection in thyroid cancer patients. This meta-analysis aims to compare the efficacy and safety across modalities.
Methods: Four databases were searched for studies on radiofrequency (RFA), microwave (MWA), laser (LA), and ethanol ablation (EA) treating metastatic cervical nodes from thyroid cancer.
The Cell Reports team recently attended the Keystone Symposia on Biological Condensates. The meeting was a great opportunity to learn about the latest developments in this exciting area. In this Voices piece, we asked three researchers in the field how the landscape of biomolecular condensate research is evolving.
View Article and Find Full Text PDFFrom phenotype to phonotype: a comprehensive description of voice features of Cri du chat syndrome.
Eur J Pediatr
December 2024
Università Cattolica del Sacro Cuore, Rome, 00168, Italy.
Article Synopsis
- Genetic syndromes have been extensively studied for their clinical signs and underlying mechanisms, but gaps remain in understanding specific aspects like vocal production in conditions such as Cri du chat syndrome (CdCS).
- A study aimed to analyze the vocal characteristics of 29 CdCS patients aged 4 to 21 by recording their pronunciations of the vowels [a], [i], and [u], as well as counting from 1 to 10.
- Results showed notable differences in vocal qualities based on age and gender, with older males exhibiting the most pronounced roughness and asthenia, highlighting the link between voice production and biological or clinical traits.
Voice Assessment in Patients with Amyotrophic Lateral Sclerosis: An Exploratory Study on Associations with Bulbar and Respiratory Function.
Brain Sci
October 2024
Department of Physiology, Institute of Molecular Medicine, Lisbon School of Medicine, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal.
Background: Speech production is a possible way to monitor bulbar and respiratory functions in patients with amyotrophic lateral sclerosis (ALS). Moreover, the emergence of smartphone-based data collection offers a promising approach to reduce frequent hospital visits and enhance patient outcomes. Here, we studied the relationship between bulbar and respiratory functions with voice characteristics of ALS patients, alongside a speech therapist's evaluation, at the convenience of using a simple smartphone.
View Article and Find Full Text PDFHeterozygous BTNL8 variants in individuals with multisystem inflammatory syndrome in children (MIS-C).
J Exp Med
December 2024
Section of Paediatric Infectious Disease, Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK.
Multisystem inflammatory syndrome in children (MIS-C) is a rare condition following SARS-CoV-2 infection associated with intestinal manifestations. Genetic predisposition, including inborn errors of the OAS-RNAseL pathway, has been reported. We sequenced 154 MIS-C patients and utilized a novel statistical framework of gene burden analysis, "burdenMC," which identified an enrichment for rare predicted-deleterious variants in BTNL8 (OR = 4.
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