This study aims to examine the effects of the underlying population distribution (normal, non-normal) and OLs on the magnitude of Pearson, Spearman and Pearson Winzorized correlation coefficients through Monte Carlo simulation. The study is conducted using Monte Carlo simulation methodology, with sample sizes of 50, 100, 250, 250, 500 and 1000 observations. Each, underlying population correlations of 0.12, 0.20, 0.31 and 0.50 under conditions of bivariate Normality, bivariate Normality with Outliers (discordant, contaminants) and Non-normal with different values of skewness and kurtosis. The results show that outliers have a greater effect compared to the data distributions; specifically, a substantial effect occurs in Pearson and a smaller one in Spearman and Pearson Winzorized. Additionally, the outliers are shown to have an impact on the assessment of bivariate normality using Mardia's test and problems with decisions based on skewness and kurtosis for univariate normality. Implications of the results obtained are discussed.
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http://dx.doi.org/10.1080/00221309.2022.2094310 | DOI Listing |
Med Phys
January 2025
Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, USA.
Purpose: In locations where the proton energy spectrum is broad, lineal energy spectrum-based proton biological effects models may be more accurate than dose-averaged linear energy transfer (LET) based models. However, the development of microdosimetric spectrum-based biological effects models is hampered by the extreme computational difficulty of calculating microdosimetric spectra. Given a precomputed library of lineal energy spectra for monoenergetic protons, a weighted summation can be performed which yields the lineal energy spectrum of an arbitrary polyenergetic beam.
View Article and Find Full Text PDFBackground And Purpose: Radiation induced image changes (IC) on MRI have been observed after proton therapy for brain tumours. This study aims to create predictive models, with and without taking into account patient variation, based on dose, linear energy transfer (LET) and periventricular zone (PVZ) in a national cohort of patients with glioma treated with pencil beam scanning (PBS).
Materials And Methods: A cohort of 87 consecutive patients with oligodendroglioma or astrocytoma (WHO grade 2-4) treated with PBS from January 2019 to December 2021 was included.
Appl Radiat Isot
January 2025
School of Artificial Intelligence, Wenzhou Polytechnic, Wenzhou, 325035, China. Electronic address:
For the purpose of assessing image quality and calculating patient X-ray dosage in radiology, computed tomography (CT), fluoroscopy, mammography, and other fields, it is necessary to have prior knowledge of the X-ray energy spectrum. The main components of an X-ray tube are an electron filament, also known as the cathode, and an anode, which is often made of tungsten or rubidium and angled at a certain angle. At the point where the electrons generated by the cathode and the anode make contact, a spectrum of X-rays with energies spanning from zero to the maximum energy value of the released electrons is created.
View Article and Find Full Text PDFAppl Radiat Isot
January 2025
Internal Dosimetry Section, Radiation Safety Systems Division, Bhabha Atomic Research Centre, Trombay, 400085, India.
Shadow Shield Whole Body Counter (SSWBC) is used to estimate internal dose of radiation workers due to the intake of fission and activation products. The SSWBC geometry was numerically modelled in FLUKA code. The computational model was validated by comparing the experimental and simulated counting efficiencies (CEs), also known as response, using Bhabha Atomic Research Centre (BARC) reference BOttle Mannequin Absorption (BOMAB) phantom.
View Article and Find Full Text PDFAppl Radiat Isot
December 2024
Instituto de Física Corpuscular (CSIC-Universidad de Valencia), Valencia, Spain.
This paper explores the adaptation and application of i-TED Compton imagers for real-time dosimetry in Boron Neutron Capture Therapy (BNCT). The i-TED array, previously utilized in nuclear astrophysics experiments at CERN, is being optimized for detecting and imaging 478 keV gamma-rays, critical for accurate BNCT dosimetry. Detailed Monte Carlo simulations were used to optimize the i-TED detector configuration and enhance its performance in the challenging radiation environment typical of BNCT.
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