California National Primate Research Center and Psychology Department, University of California, Davis, California, USA.
Published: December 2022
AI Article Synopsis
Article Abstract
We conducted a dose-response study of dexamethasone to investigate an optimal dexamethasone suppression test for common marmosets. Twelve marmosets received 0.1, 0.5, or 1.0 mg/kg dexamethasone. Doses of 0.5 and 1.0 mg/kg both suppressed endogenous cortisol for at least 18 h with greater individual variability in the lower 0.5 mg/kg dose.
The common marmoset (Callithrix jacchus) has attracted much attention as a nonhuman primate animal model for stress-related experiments. The adrenal gland plays a key role in stress responses and has abundant vasculature, through which the hypothalamic-pituitary axis hormonally controls its activity. Understanding the arterial supply pattern to the gland is fundamental to understanding its function and performing experiments.
Unlabelled: Nonhuman primates (NHPs) are pivotal for unlocking the complexities of human cognition, yet traditional cognitive studies remain constrained to specialized laboratories. To revolutionize this paradigm, we present : an open-source, scalable in-cage platform tailored for freely behaving experiments in small primate species such as the common marmoset ( ). includes modular operant chambers that operate autonomously and integrate seamlessly with home cages, eliminating human intervention.
Biological neural networks, especially in the visual cortex of different species, process information through both spontaneous and stimulus-evoked activities, but how they handle internal noise vs. sensory signals is debated.
In mouse primary visual cortex (V1), spontaneous and stimulus-evoked activities reveal dissimilar patterns, aiding in the separation of sensory information from noise, while higher similarity is observed in carnivores and primates.
The study found that in marmosets, while V1 shows similar spontaneous and stimulus-evoked activity, higher visual areas exhibit an increasing orthogonalization of these patterns, suggesting a broader principle of cortical computation across species.
The relationships between members of the groups include behaviors related to affiliation, dispute for dominant positions, parental care, and facing disputes for food and territory. All these activities are under hormone modulation and those of a steroidal nature are heavily involved. Despite this, only few data are available on steroid hormones in free-ranging marmosets of the genus, which limits the understanding of the physiological functioning and modulation of the socio-sexual behavior by steroid hormones of this taxon.
Mechanisms of computation in sensorimotor cortex must be flexible and robust to support skilled motor behavior. Patterns of neuronal coactivity emerge as a result of computational processes. Pairwise spike-time statistical relationships, across the population, can be summarized as a functional network (FN) which retains single-unit properties.
