AI Article Synopsis
- The DRAGON 1 trial investigates the training, implementation, safety, and feasibility of a combined portal- and hepatic-vein embolization (PVE/HVE) approach to encourage liver growth in patients with borderline resectable colorectal cancer liver metastases.
- The study is a worldwide multicenter, single-arm trial, with primary endpoints focusing on the safety of the procedure and 90-day mortality, while secondary endpoints look at resection feasibility, liver function, and overall survival rates.
- The findings aim to standardize procedures for future trials and enhance understanding of the safety and effects of PVE/HVE on liver growth in this patient population.
Article Abstract
Study Purpose: The DRAGON 1 trial aims to assess training, implementation, safety and feasibility of combined portal- and hepatic-vein embolization (PVE/HVE) to accelerate future liver remnant (FLR) hypertrophy in patients with borderline resectable colorectal cancer liver metastases.
Methods: The DRAGON 1 trial is a worldwide multicenter prospective single arm trial. The primary endpoint is a composite of the safety of PVE/HVE, 90-day mortality, and one year accrual monitoring of each participating center. Secondary endpoints include: feasibility of resection, the used PVE and HVE techniques, FLR-hypertrophy, liver function (subset of centers), overall survival, and disease-free survival. All complications after the PVE/HVE procedure are documented. Liver volumes will be measured at week 1 and if applicable at week 3 and 6 after PVE/HVE and follow-up visits will be held at 1, 3, 6, and 12 months after the resection.
Results: Not applicable.
Conclusion: DRAGON 1 is a prospective trial to assess the safety and feasibility of PVE/HVE. Participating study centers will be trained, and procedures standardized using Work Instructions (WI) to prepare for the DRAGON 2 randomized controlled trial. Outcomes should reveal the accrual potential of centers, safety profile of combined PVE/HVE and the effect of FLR-hypertrophy induction by PVE/HVE in patients with CRLM and a small FLR.
Trial Registration: Clinicaltrials.gov: NCT04272931 (February 17, 2020). Toestingonline.nl: NL71535.068.19 (September 20, 2019).
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9458562 | PMC |
| http://dx.doi.org/10.1007/s00270-022-03176-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Moving Towards the Outpatient DIEP Flap: Factors Influencing Early Discharge.
Plast Reconstr Surg
December 2024
Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
Background: Enhanced Recovery After Surgery (ERAS) protocols can reduce the length of stay (LOS) for surgical patients, including those undergoing unilateral deep inferior epigastric artery perforator (DIEP) flap breast reconstruction, allowing most patients to be discharged by postoperative day 2. However, some patients require a prolonged inpatient stay due to difficulty completing postoperative milestones. This study aims to identify factors associated with increased LOS after DIEP flap breast reconstruction and assess safety of earlier discharge.
View Article and Find Full Text PDFAssessing and Improving the Documentation of Large-Volume Paracentesis Procedures in a Tertiary Hospital: A Quality Improvement Project.
Cureus
November 2024
Gastroenterology and Hepatology, Barts Health NHS Trust, London, GBR.
Inconsistent documentation of large-volume paracentesis (LVP) procedures in a tertiary hospital presents risks to patient safety and procedural quality. This study aimed to improve the completeness and accuracy of LVP documentation through the implementation of a structured checklist, developed in alignment with the British Society of Gastroenterology (BSG) Safety Toolkit. The intervention was conducted over three Plan-Do-Study-Act (PDSA) cycles and involved multidisciplinary collaboration, the integration of Local Safety Standards for Invasive Procedures (LocSSIPs) into the Clinical Record System (CRS), and targeted training for staff.
View Article and Find Full Text PDFPerception of patient safety culture among undergraduate dental students: a cross-sectional study.
BMC Med Educ
December 2024
Department of Oral Biology, Sindh Institute of Oral Health Sciences, Jinnah Sindh Medical University, Karachi, Pakistan.
Objectives: Although patient safety has received a lot of emphasis in medicine and nursing, data regarding patient safety perception in dentistry are limited, particularly among dental students. Given the increasing risk of safety hazards, curriculum developers need evidence to guide their implementation in undergraduate studies. This study aimed to determine patient safety culture among undergraduate dental students in Pakistan.
View Article and Find Full Text PDFHealthPass: a contactless check-in and adaptive access control system for lowering cluster infection risk in public health crisis.
Front Public Health
December 2024
Fujian Key Laboratory of Sensing and Computing for Smart Cities, School of Informatics, Xiamen University, Xiamen, China.
Introduction: Ensuring effective measures against the spread of the virus is paramount for educational institutions and workplaces as they resume operations amidst the ongoing public health crisis. A touchless and privacy-conscious check-in procedure for visitor assessment is critical to safeguarding venues against potential virus transmission.
Methods: In our study, we developed an interaction-free entry system featuring anonymous visitors who voluntarily provide data.
Implementation and evaluation of whole-course-based Internet Hospital Outpatient Pharmacy Services: a cross-sectional study in western China.
Front Public Health
December 2024
Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, China.
Background: In recent years, the development of telemedicine and eHealth services has led to the rapid worldwide growth of Internet hospitals, which played a significant role during the coronavirus disease 2019 (COVID-19) pandemic. However, little is known about the characteristics and safety of Internet hospital outpatient pharmacy services (IHOPSs), which represent a new model of pharmaceutical services.
Objective: This study aimed to reveal the comprehensive characteristics and safety of whole-course-based IHOPSs in a general tertiary hospital in western China.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!