The first work on noogenesis as evolution of intellect was published 150 years ago. However, it was not until the 21st century that quantitation became possible for certain parameters that contribute to the understanding of the evolution of intellectual systems in natural sciences, the progress being due to basic achievements in physics, biology, medicine, and interdisciplinary fields. Analyses of the parameters of intellectual systems, patterns of their emergence and evolution, distinctive features, and the constants and limits of their structures and functions made it possible to measure and compare the capacity of communications (~100 to 300 million m/s), to quantify the number of components in intellectual systems (10-100 billion components), and to calculate the number of successful links responsible for cooperation (from 150 to 1 trillion links). Prognostic models can be developed by studying the phenomenon of the origin and evolution of the brain as a population of neurons within the biological evolution of and the advent of cognition; by studying the brain of an individual throughout individual anatomic and physiological development, including the development of creativity, thinking, consciousness, idea, insight, intuition, and eureka; and by studying and "noo" in the context of the hypothesis of the morphological and functional evolution of the human population.
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http://dx.doi.org/10.1134/S0006350922020051 | DOI Listing |
Res Dev Disabil
January 2025
Department of Psychology and Cognitive Science, University of Trento, Rovereto, Italy. Electronic address:
Quality of Life (QoL) is a crucial concept that pertains to an individual's perception of their position in life. In the context of developmental disabilities, QoL is pivotal for improving evidence-based practices, providing support and organizing services for individuals, thereby enabling them to achieve their potential with dignity and equality. Despite its importance, QoL has often not been the primary focus in many studies on developmental disabilities and remains less developed compared to other research areas.
View Article and Find Full Text PDFInt J Med Inform
January 2025
Oulu Advanced Research on Service and Information Systems, University of Oulu, Linnanmaa campus, Pentti Kaiteran katu 1 90570 Oulu, Finland. Electronic address:
Background: Studies have demonstrated that interventions targeting weight loss and body mass index (BMI) reduction can be successful, although the specific factors that influence their effectiveness are still unclear. Behavior change support systems (BCSS) are an approach that aims to help users in their efforts to modify their behavior. A useful tool for assessing BCSS is the Persuasive Systems Design model (PSD), where different features and postulates can be employed.
View Article and Find Full Text PDFCell Rep
January 2025
Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA; The Brain Tumor Center, Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:
Mutation or deletion of the deubiquitinase USP7 causes Hao-Fountain syndrome (HAFOUS), which is characterized by speech delay, intellectual disability, and aggressive behavior and highlights important unknown roles of USP7 in the nervous system. Here, we conditionally delete USP7 in glutamatergic neurons in the mouse forebrain, triggering disease-relevant phenotypes, including sensorimotor deficits, impaired cognition, and aggressive behavior. Although USP7 deletion induces p53-dependent neuronal apoptosis, most behavioral abnormalities in USP7 conditional knockout mice persist following p53 loss.
View Article and Find Full Text PDFJ Clin Med
January 2025
Owerko Centre at the Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB T2N 1N4, Canada.
: Our understanding of the transdiagnostic factors that influence health-related quality of life (HRQOL) in individuals with neurodivergent conditions is very sparse and highly siloed by diagnosis labels. Research on transdiagnostic predictors of HRQOL across neurodevelopmental conditions is needed to enable care models that address shared needs of neurodivergent individuals beyond diagnostic boundaries. Our objective was to identify transdiagnostic factors associated with HRQOL in children with autism, epilepsy, or comorbid autism/epilepsy.
View Article and Find Full Text PDFWorld J Biol Psychiatry
January 2025
Division of Genetics, Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.
Background: Genes associated with global developmental delay (GDD) and intellectual disability (ID) are increasingly being identified through next-generation sequencing (NGS) technologies. This study aimed to identify novel mutations in GDD/ID phenotypes through whole-exome sequencing (WES) and additional analyses.
Material And Methods: WES was performed on 27 subjects, among whom 18 were screened for potential novel mutations.
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