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Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy. | LitMetric
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Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy.

Jiaqi Yan Haixia Zou Wenhui Zhou Xiaowan Yuan Zhijun Li Xiaodong Ma Chang Liu Yonghui Wang Jessica M Rosenholm Wenguo Cui Xiangmeng Qu Hongbo Zhang

Biomater Sci

Department of Radiology, Shanghai Institute of Traumatology and Orthopaedics, RuiJin Hospital, Shanghai Jiao Tong University, 149 ChongqingNan Road, Shanghai, 200020, PR China.

Published: July 2022

Herein, a smart nanohydrogel with endogenous microRNA-21 toehold is developed to encapsulate gemcitabine-loaded mesoporous silica nanoparticles for targeted pancreatic cancer therapy. This toehold mediated strand displacement method can simultaneously achieve specific drug release and miRNA-21 silencing, resulting in the up-regulation of the expression of tumor suppressor genes PTEN and PDCD4.

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 Source
http://dx.doi.org/10.1039/d2bm00640eDOI Listing

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