A man in his 70s presented to the emergency department with ongoing chest pain, which started directly after receiving sclerotherapy for the treatment of varicose veins. This was on a background of experiencing short-term chest pain twice previously following sclerotherapy. By the time he was seen, his pain had reduced significantly. ECG showed subtle ischaemic changes. Troponins were significantly raised. A transthoracic echocardiogram demonstrated apical akinesis. Coronary arteries were patent on angiography. A repeat echocardiogram in 4 weeks showed complete resolution of ventricular dysfunction. This represents the first reported case of Takotsubo cardiomyopathy following sclerotherapy in the UK. This case provides a useful learning opportunity for clinicians, to consider immediate investigation in the context of chest pain following sclerotherapy, and how to practically distinguish between Takotsubo cardiomyopathy and myocardial infarction in the differential diagnosis.
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http://dx.doi.org/10.1136/bcr-2022-250899 | DOI Listing |
CJC Open
February 2025
Division of Cardiology, University of Ottawa Heart Institute, University of Ottawa, Ottawa, Ontario, Canada.
J Cardiovasc Med (Hagerstown)
April 2025
Clinical Cardiology Unit, Department of Medical Sciences and Public Health, University of Cagliari.
Aims: Takotsubo syndrome (TTS) is usually triggered by either physical/psychological stressors or comorbidities, neurological among others. The prevalence of amyotrophic lateral sclerosis (ALS) among TTS and whether it has a worse clinical course is not known. We aim to describe ALS prevalence and its impact on clinical presentation, clinical course, and long-term mortality.
View Article and Find Full Text PDFThis case of Takotsubo syndrome in a young, non-stressed female highlight that it can present across various ages and ECG patterns, suggesting a need for further genetic research. In ECGs showing ST-elevation myocardial infarction (STEMI), non-invasive coronary evaluation should be prioritized over direct angiography. Echocardiographic GLS strain can help predict prognosis and facilitate early recovery.
View Article and Find Full Text PDFHeart Views
January 2025
Department of Cardiology, Heart Hospital, Hamad Medical Corporation, Doha, Qatar.
A 68-year-old elderly individual presented with takotsubo cardiomyopathy, and echocardiography revealed left ventricular outflow tract obstruction with a substantial gradient, particularly exacerbated by the Valsalva maneuver. Resolution occurred within a few days through meticulous fluid management and beta-blocker administration, concurrent with an improvement in ejection fraction.
View Article and Find Full Text PDFAm J Clin Oncol
February 2025
Department of Internal Medicine, Icahn School of Medicine at Mount Sinai/BronxCare Health System, New York, NY.
Objectives: Immune checkpoint inhibitors (ICI) upregulate host antitumor immunity, proving efficacy across diverse tumor types. Currently approved ICI treatment primarily targets the programmed cell death receptor 1 (PD-1) and its ligand PD-L1, and cytotoxic T lymphocyte-antigen 4 (CTLA-4). Nivolumab is a monoclonal antibody that targets the human PD-1 receptor and is an entirely human immunoglobulin G4 (IgG4), approved by the FDA for various cancers like advanced melanoma, metastatic renal cell carcinoma, Hodgkin lymphoma, and advanced lung carcinoma.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!