The olfactory perception in matched groups of 26 smokers, 26 nonsmokers, and 15 passive smokers was examined psychophysically with two substances, n-butane and pyridine. Different psychophysical functions were obtained from these groups using the method of magnitude estimation. The smokers and passive smokers perceived all concentrations of n-butane to be weaker than did the nonsmokers. In the case of pyridine, a substance in tobacco smoke to which smokers are more exposed, there is an indication of a perceptual deficit similar to loudness recruitment. There were no appreciable differences between smokers and nonsmokers for high concentrations; the sensitivity was less and the psychophysical functions steeper for smokers than nonsmokers for relatively low concentrations. The results are evaluated in terms of information about the subjects' response criteria, and the authors consider the possibility of sensory deficit versus habituation.
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http://dx.doi.org/10.1016/s0196-0709(87)80011-x | DOI Listing |
Quant Imaging Med Surg
January 2025
Department of Positron Emission Tomography/Computed Tomography, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Background: With an increasing number of smokers who consume fewer cigarettes, it is crucial to understand the lung structure changes of low-intensity smoking. This study aimed to investigate the lung structure changes in low-intensity smokers in a Chinese male cohort.
Methods: Chest computed tomography (CT) examinations of 465 asymptomatic healthy male participants were divided into non-smoking (n=256), light-smoking (n=84), intermediate-smoking (n=85), and heavy-smoking (n=40) groups.
BMC Med
January 2025
The Second Affiliated Hospital, School of Public Health, Zhejiang University School of Medicine, 388 Yuhangtang Road, Hangzhou, 310058, Zhejiang, China.
Background: Cigarette smoking is posited as a potential factor in disrupting the balance of the human gut microbiota. However, existing studies with limited sample size have yielded inconclusive results.
Methods: Here, we assessed the association between cigarette smoking and gut microbial profile among Chinese males from four independent studies (N total = 3308).
BMC Pulm Med
January 2025
İzmir International Biomedicine and Genome Institute, Dokuz Eylül University, İzmir, Türkiye.
Purpose: The inflammatory response in animal models of chronic obstructive pulmonary disease (COPD) is activated by the NLR-family-pyrin-domain-containing-3 (NLRP3) inflammasome pathway, which is also known to play a role in obesity-related inflammation. The NLRP3/caspase-1/interleukin (IL)-1β pathway might be involved in the progression of COPD with increasing body mass index. To our knowledge, no previous studies have explored the role of NLRP3 inflammasome markers in linking COPD and obesity.
View Article and Find Full Text PDFInjury
January 2025
Department of Orthopaedic Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, United States of America.
Introduction: Studies have demonstrated successful outcomes with early weightbearing following open reduction internal fixation (ORIF) of specific ankle fractures. The external validity of an early weightbearing protocol and its effects on patient-reported outcome information scores (PROMIS) has yet to be investigated. This study aimed to investigate the effects of an early weightbearing protocol for all operatively treated ankle fractures and its impact on clinical outcomes and complications.
View Article and Find Full Text PDFJ Clin Psychopharmacol
January 2025
Department of Psychological Medicine, University of Otago, Wellington, New Zealand.
Background: Sodium valproate has been coprescribed with clozapine for seizure prophylaxis and for augmentation in treatment-refractory schizophrenia. However, the effect of valproate on clozapine metabolism and on the incidence of clozapine-related side effects is unclear.
Methods: We compared clozapine dose and plasma clozapine and N-desmethylclozapine (norclozapine) concentrations in smokers and nonsmokers of both sexes in samples submitted for clozapine therapeutic drug monitoring, 1996-2017 in relation to valproate coprescription.
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