We report the conformation of a newly discovered specific lanthanide ion (Ln) binding protein, lanmodulin (LanM), and its interaction with Ln in cells using the in-cell NMR technique. We found that LanM remains unfolded and fails to bind Ln in cells due to the abundance of phosphate groups.
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http://dx.doi.org/10.1039/d2cc02038f | DOI Listing |
Biomed Eng Lett
January 2025
Electronics and Communication Engineering, IFET College of Engineering, Villupuram, Tamilnadu India.
Unlabelled: Breast cancer (BC) remains a significant global health issue, necessitating innovative methodologies to improve early detection and diagnosis. Despite the existence of intelligent deep learning models, their efficacy is often limited due to the oversight of small-sized masses, leading to false positive and false negative outcomes. This research introduces a novel segmentation-guided classification model developed to increase BC detection accuracy.
View Article and Find Full Text PDFFam Process
March 2025
School of Counseling and Counseling Psychology, Arizona State University, Tempe, Arizona, USA.
Research and theory document links between sacrifices and commitment in couples, yet the direction of effects remains unclear. Whereas interdependence theorists suggest that sacrifices help couples to build commitment, other scholars have suggested that being committed leads partners to sacrifice for each other. Nearly all research in this area has focused on men and women in different-gender relationships with each other.
View Article and Find Full Text PDFCurr Hematol Malig Rep
January 2025
Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Purpose Of Review: More than a decade following the discovery of Calreticulin (CALR) mutations as drivers of myeloproliferative neoplasms (MPN), advances in the understanding of CALR-mutant MPN continue to emerge. Here, we summarize recent advances in mehanistic understanding and in targeted therapies for CALR-mutant MPN.
Recent Findings: Structural insights revealed that the mutant CALR-MPL complex is a tetramer and the mutant CALR C-terminus is exposed on the cell surface.
Cells
December 2024
Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad de Sevilla (US), 41012 Sevilla, Spain.
Autophagy is a catabolic process involved in different cellular functions. However, the molecular pathways governing its potential roles in different cell types remain poorly understood. We investigated the role of autophagy in the context of proteotoxic stress in two central nervous system cell types: the microglia-like cell line BV2 and the neuronal-like cell line N2a.
View Article and Find Full Text PDFBiomolecules
November 2024
Department of Cardiology, Hygeia Hospital, 15123 Athens, Greece.
Myocardial cells and the extracellular matrix achieve their functions through the availability of energy. In fact, the mechanical and electrical properties of the heart are heavily dependent on the balance between energy production and consumption. The energy produced is utilized in various forms, including kinetic, dynamic, and thermal energy.
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