Lanmodulin remains unfolded and fails to interact with lanthanide ions in cells.

Chem Commun (Camb)

Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan National Laboratory for Optoelectronics, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, 430071, China.

Published: July 2022

We report the conformation of a newly discovered specific lanthanide ion (Ln) binding protein, lanmodulin (LanM), and its interaction with Ln in cells using the in-cell NMR technique. We found that LanM remains unfolded and fails to bind Ln in cells due to the abundance of phosphate groups.

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http://dx.doi.org/10.1039/d2cc02038fDOI Listing

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