The soaking strategy with the Hofmeister effect has been proposed to fabricate gelatin- based hydrogels with excellent properties. However, the modulation mechanism of hydrogels lacks in-depth study. In this work, we studied in detail the effects of Hofmeister ions on the structural, thermal, viscoelastic and mechanical properties of gelatin hydrogels. The results showed that kosmotropic anions (Cit, SO, HPO and SO) enhanced hydrogen bonds and hydrophobic interactions between gelatin molecules, resulting in increases in the length and content of triple helices and thus improving the properties of gelatin hydrogels. In contrast, chaotropic anions (I and SCN) weakened the interactions between gelatin molecules, and thus attenuated the properties. Based on the Hofmeister effect, we successfully fabricated gelatin poly N-methylolacrylamide (PNMA) double network hydrogels with shape memory properties. The Hofmeister effect provides an excellent route for the rational design and fabrication of functional gelatin-based hydrogels.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.colsurfb.2022.112674 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Fast-Relaxing Hydrogels Promote Pancreatic Adenocarcinoma Cell Aggressiveness through Integrin β1 Signaling.
Biomacromolecules
January 2025
Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, United States.
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense extracellular matrix (ECM) exhibiting high stiffness and fast stress relaxation. In this work, gelatin-based viscoelastic hydrogels were developed to mimic the compositions, stiffness, and fast stress relaxation of PDAC tissues. The hydrogels were cross-linked by gelatin-norbornene-boronic acid (GelNB-BA), thiolated macromers, and a 1,2-diol-containing linear synthetic polymer PHD.
View Article and Find Full Text PDFConductive hydrogel luminal filler for peripheral nerve regeneration.
Biomaterials
January 2025
School of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea. Electronic address:
Peripheral nerve injuries impair quality of life due to pain and loss of sensory and motor functions. Current treatments like autografts and nerve guidance conduits (NGCs) have limitations in functional restoration. Luminal fillers can enhance the effectiveness of NGCs by providing beneficial intraneural environments.
View Article and Find Full Text PDF3D Bioprinted Head and Neck Squamous Cell Carcinoma (HNSCC) Model Using Tunicate Derived Nanocellulose (NC) Bioink.
Adv Healthc Mater
January 2025
Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, German Red Cross Blood Donor Service Baden-Württemberg - Hessen, 68167, Mannheim, Germany.
Head and neck squamous cell carcinoma (HNSCC) are invasive solid tumors accounting for high mortality. To improve the clinical outcome, a better understanding of the tumor and its microenvironment (TME) is crucial. Three -dimensional (3D) bioprinting is emerging as a powerful tool for recreating the TME in vitro.
View Article and Find Full Text PDFInjectable Gelatin-Palmitoyl-GDPH Hydrogels as Bioinks for Future Cutaneous Regeneration: Physicochemical Characterization and Cytotoxicity Assessment.
Polymers (Basel)
December 2024
Department of Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, Malaysia.
Tissue engineering and regenerative medicine have made significant breakthroughs in creating complex three-dimensional (3D) constructs that mimic human tissues. This progress is largely driven by the development of hydrogels, which enable the precise arrangement of biomaterials and cells to form structures resembling native tissues. Gelatin-based bioinks are widely used in wound healing due to their excellent biocompatibility, biodegradability, non-toxicity, and ability to accelerate extracellular matrix formation.
View Article and Find Full Text PDFChemically defined and dynamic click hydrogels support hair cell differentiation in human inner ear organoids.
Stem Cell Reports
December 2024
Department of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Electronic address:
The mechanical properties in the inner ear microenvironment play a key role in its patterning during embryonic development. To recapitulate inner ear development in vitro, three-dimensional tissue engineering strategies including the application of representative tissue models and scaffolds are of increasing interest. Human inner ear organoids are a promising model to recapitulate developmental processes; however, the current protocol requires Matrigel that contains ill-defined extracellular matrix components.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!