AI Article Synopsis
- Ebola virus (EBOV) has a very high case mortality rate (up to 89%) and exhibits symptoms similar to other diseases, making diagnosis challenging.
- There is a significant need for fast and accurate diagnostics to improve patient outcomes, especially since timely treatment can greatly impact survival rates.
- This study introduces a rapid diagnostic method utilizing microring resonator sensors to detect a specific biomarker (soluble glycoprotein) of EBOV in under 40 minutes, proving its effectiveness with samples from infected non-human primates.
Article Abstract
Ebola virus (EBOV) is a highly infectious pathogen, with a case mortality rate as high as 89%. Rapid therapeutic treatments and supportive measures can drastically improve patient outcome; however, the symptoms of EBOV disease (EVD) lack specificity from other endemic diseases. Given the high mortality and significant symptom overlap, there is a critical need for sensitive, rapid diagnostics for EVD. Facile diagnosis of EVD remains a challenge. Here, we describe a rapid and sensitive diagnostic for EVD through microring resonator sensors in conjunction with a unique biomarker of EBOV infection, soluble glycoprotein (sGP). Microring resonator sensors detected sGP in under 40 min with a limit of detection (LOD) as low as 1.00 ng/mL in serum. Furthermore, we validated our assay with the detection of sGP in serum from EBOV-infected non-human primates. Our results demonstrate the utility of a high-sensitivity diagnostic platform for detection of sGP for diagnosis of EVD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243524 | PMC |
| http://dx.doi.org/10.1016/j.crmeth.2022.100234 | DOI Listing |
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