AI Article Synopsis
- ILC2s are a type of immune cell that produce type 2 cytokines and were first found in adipose tissue.
- They are present in other tissues like the lungs and skin, acting as tissue-resident immune cells that help maintain tissue balance.
- The review highlights current knowledge on ILC2 biology and suggests future research directions, especially related to their role in adipose tissue and metabolic health.
Article Abstract
Group 2 innate lymphoid cells (ILC2s) were initially identified as a new type of lymphocytes that produce vigorous amounts of type 2 cytokines in adipose tissue. Subsequent studies revealed that ILC2s are present not only in adipose tissue but also in various other tissues such as lung and skin. ILC2s are generally recognized as tissue-resident immune cells that regulate tissue homeostasis. ILC2s express receptors for various humoral factors and thus can change their functions or distribution depending on the environment and circumstances. In this review, we will outline our recent understanding of ILC2 biology and discuss future directions for ILC2 research, particularly in adipose tissue and metabolic homeostasis.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243262 | PMC |
| http://dx.doi.org/10.3389/fimmu.2022.876029 | DOI Listing |
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