Background: The rise in the use of prescription opioids for postoperative analgesia within surgery has mirrored an increased trend of opioid-related morbidity within Canada and the United States. This study prospectively studied daily pain levels and medication requirements postoperatively in patients undergoing elective Otolaryngology-Head and Neck surgery procedures.
Methods: Patients were asked to prospectively document their pain level and medication use daily for 7 days postoperatively. A final survey was used to quantify unused medication left at home and clarify each patient's disposal plan. We included patients undergoing elective outpatient or short stay surgeries from three tertiary care centers in Toronto, Ontario from September 2016 to September 2017. Previous opioids users or patients suffering from chronic pain were excluded.
Results: A final cohort of 56 eligible adult patients were included in the study. The most common procedures were thyroidectomy ( = 19), endoscopic sinus surgery ( = 10), tympanoplasty/ossiculoplasty ( = 7), and cochlear implant ( = 5). Most patients received a prescription for acetaminophen/codeine ( = 29, 51.8%) or acetaminophen/oxycodone ( = 22, 39.3%) and used on average 29% of their initial prescription. Patients most commonly opted to keep their unused narcotics at home ( = 23, 41%). A total of 710 tablets of narcotics were overprescribed in our study population, 351 of which were kept in patients' home for future use.
Conclusion: There is a clear tendency to overestimate postoperative pain resulting in significant overprescription of opioids among Otolaryngologists.
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http://dx.doi.org/10.1002/wjo2.19 | DOI Listing |
Eur J Med Res
January 2025
Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, China.
Objectives: SOX10 is crucially implicated in various cancer, yet the regulatory role in pancreatic cancer (PC) remains enigmatic. Underlying molecular mechanisms of SOX10 in PC were explored in our study.
Methods: Relationships between SOX10 and immune landscape were estimated using bioinformatic approaches.
BMC Surg
January 2025
Department of Otolaryngology-Head and Neck Surgery, Zhangqiu People's Hospital, No.1920 Mingshui Huiquan Road, Zhangqiu Distict, Jinan, 250200, People's Republic of China.
Background: To prospectively determine whether tympanoplasty for tympanic membrane perforation (TMP) in wet ears impacts recovery.
Methods: We prospectively enrolled 32 TMP patients (2021-2023) and divided them into the wet-ear (14 patients) and dry-ear groups (18 patients), according to the presence of middle-ear secretions/edema. All patients underwent high-resolution thin-slice computed tomography, ear endoscopy, and pure tone audiometry.
Nat Commun
January 2025
Shanghai Institute of Precision Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Vangl is a planar cell polarity (PCP) core protein essential for aligned cell orientation along the epithelial plane perpendicular to the apical-basal direction, which is important for tissue morphogenesis, development and collective cell behavior. Mutations in Vangl are associated with developmental defects, including neural tube defects (NTDs), according to human cohort studies of sporadic and familial cases. The complex mechanisms underlying Vangl-mediated PCP signaling or Vangl-associated human congenital diseases have been hampered by the lack of molecular characterizations of Vangl.
View Article and Find Full Text PDFBMJ Open
January 2025
Department of Epidemiology, School of Public Health, St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia
Objectives: To assess the prevalence and associated factors of hearing loss in Ethiopia, considering socioeconomic conditions, regional variations and age-related impacts.
Design: Nationwide cross-sectional survey.
Setting: Data were collected from 2 February to 10 June 2023, covering all regions of Ethiopia except Tigray (due to security concerns).
Surg Innov
January 2025
Department of Otolaryngology - Head & Neck Surgery, Kirk Kerkorian School of Medicine at UNLV, Las Vegas, NV, USA.
Objective: The Thunderbeat (TB) is a new surgical device that combines ultrasonic and bipolar energy. The objective of this study is to examine how the combined ultrasonic and bipolar shears affect surgical outcomes when compared to other methods.
Data Sources And Review Methods: Using the PRISMA guidelines, the researchers used broad search terms in PubMed, Embase, and Web of Science, which produced a total of 2823 initial results, with years ranging from 1955 to June 2024.
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