AI Article Synopsis
- Ghrelin is a hormone produced in the stomach and brain that plays a role in stimulating growth hormone and appetite, but it's also linked to mood disorders like depression.
- Research indicates that ghrelin can both increase and decrease symptoms of depression in animals, suggesting it has a complex role in emotional regulation.
- Understanding how ghrelin interacts with other neurochemical systems could lead to new treatments for depression, highlighting its potential as a target for therapy.
Article Abstract
Ghrelin is a peptide released by the endocrine cells of the stomach and the neurons in the arcuate nucleus of the hypothalamus. It modulates both peripheral and central functions. Although ghrelin has emerged as a potent stimulator of growth hormone release and as an orexigenic neuropeptide, the wealth of literature suggests its involvement in the pathophysiology of affective disorders including depression. Ghrelin exhibits a dual role through the advancement and reduction of depressive behavior with nervousness in the experimental animals. It modulates depression-related signals by forming neuronal networks with various neuropeptides and classical neurotransmitter systems. The present review emphasizes the integration and signaling of ghrelin with other neuromodulatory systems concerning depressive disorders. The role of ghrelin in the regulation of neurosynaptic transmission and depressive illnesses implies that the ghrelin system modulation can yield promising antidepressive therapies.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240712 | PMC |
| http://dx.doi.org/10.1016/j.crphar.2022.100113 | DOI Listing |
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