Capturing psychological, emotional, and physiological states, especially during a pandemic, and leveraging the captured sensory data within the pandemic management ecosystem is challenging. Recent advancements for the Internet of Medical Things (IoMT) have shown promising results from collecting diversified types of such emotional and physical health-related data from the home environment. State-of-the-art deep learning (DL) applications can run in a resource-constrained edge environment, which allows data from IoMT devices to be processed locally at the edge, and performs inferencing related to in-home health. This allows health data to remain in the vicinity of the user edge while ensuring the privacy, security, and low latency of the inferencing system. In this article, we develop an edge IoMT system that uses DL to detect diversified types of health-related COVID-19 symptoms and generates reports and alerts that can be used for medical decision support. Several COVID-19 applications have been developed, tested, and deployed to support clinical trials. We present the design of the framework, a description of our implemented system, and the accuracy results. The test results show the suitability of the system for in-home health management during a pandemic.
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http://dx.doi.org/10.1109/JIOT.2021.3051080 | DOI Listing |
During nervous system development, diverse types of neurons and glia are sequentially generated by self-renewing neural stem cells (NSCs). Temporal changes in gene expression within NSCs are thought to regulate neural diversity; however, the mechanisms regulating the timing of these temporal gene transitions remain poorly understood. type II NSCs, like human outer radial glia, divide to self-renew and generate intermediate neural progenitors, amplifying and diversifying the population of neurons innervating the central complex, a brain region required for sensorimotor coordination.
View Article and Find Full Text PDFJ Clin Med
January 2025
Laboratory of Posturology, Collegium Medicum, Jan Kochanowski University, Al. IX Wieków Kielc 19, 25-317 Kielce, Poland.
: Body posture is developmentally variable and individually diversified. As a chain of numerous unconditioned and conditioned reflexes, it is, in its essence, a psychomotor habit. The aim of the study was to create an original typology of body posture based on measurements using the Diers Formetric III 4D system.
View Article and Find Full Text PDFSci Rep
January 2025
Guilin University of Technology Institute of Earth Science, Guilin, 541004, People's Republic of China.
To diversify wine production in Xinjiang and address the issue of wine homogenization, it is crucial to leverage the unique climatic advantages of each grape-producing area to foster a high-quality wine industry. Using meteorological data from 80 national standard meteorological stations in Xinjiang, spanning 1961 to 2019, this study established a climatic zoning index system tailored to distinct grape varieties for wines, including dry red, dry white, ice wine, sparkling wine, and natural sweet wines. The system is formulated based on key climatic factors such as the frost-free period, ≥ 10 °C active accumulated temperature (AAT10), mean temperature of the coldest month, annual extreme minimum temperature, and dryness.
View Article and Find Full Text PDFbioRxiv
January 2025
Department of Systems Biology, Blavatnik Institute at Harvard Medical School, Boston, MA 02115.
Dorsal-ventral patterning of neural progenitors in the posterior neural tube, which gives rise to the spinal cord, has served as a model system to understand how extracellular signals organize developing tissues. While previous work has shown that signaling gradients diversify progenitor fates at the dorsal and ventral ends of the tissue, the basis of fate specification in intermediate regions has remained unclear. Here we use zebrafish to investigate the neural plate, which precedes neural tube formation, and show that its pre-patterning by a distinct signaling environment enables intermediate fate specification.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Laboratory of Tropical Veterinary Medicine and Vector Biology, School of Life and Health Sciences, Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of One Health, Hainan University, Haikou, Hainan 570228, China.
Insect phenoloxidase, presented as an inactive precursor prophenoloxidase (PPO) in hemolymph, catalyzes melanin formation, which is involved in wound healing, pathogen killing, reversible oxygen collection during insect respiration, and cuticle and eggshell formation. Mosquitoes possess 9 to 16 PPO members across different genera, a number that is more than that found in other dipteran insects. However, the reasons for the redundancy of these PPOs and whether they have distinct biochemical properties and physiological functions remain unclear.
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