AI Article Synopsis
- * Extensive microbiological analysis techniques like Gram staining and MALDI-TOF MS confirmed the bacterium's identity, showing 99.2% homology with known strains, alongside antibiotic susceptibility testing for effective treatment options.
- * The study, marking the first reported case of this specific bacteremia in China, underscores the emerging nature of this pathogen and the importance of recognizing lesser-known microorganisms in clinical settings.
Article Abstract
Bacteremia caused by is relatively rare in positive blood cultures. is an opportunistic bacterium in patients with cancer and cirrhosis and has also been described in immunocompromised hosts. In this study, was isolated from a patient with repeated chest tightness and chest pain. Smears were prepared, stained, and examined by microscopy. Single colonies were analyzed by Gram staining, matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS), 16S rRNA sequencing and Next-Generation Sequencing (NGS). Antibiotic sensitivity was assessed by agar dilution. Almost all publications on infections in the PubMed/ScienceDirect/EBSCO databases were reviewed and summarized. Blood sample culturing yielded white, gelatinous, and slightly raised colonies without hemolytic rings. The bacilli were found to be Gram-negative, and MS results showed 99.2% homology with . This was confirmed by 16S rRNA gene sequencing, phylogenetic tree analysis and NGS all of which were homologous with in GenBank. Antibiotic susceptibility tests were performed to determine the minimum inhibitory concentrations (MICs) of imipenem, meropenem, piperacillin-tazobactam, and levofloxacin. A comprehensive literature review revealed that was an emergent pathogen. After medical treatment, the patient's body temperature returned to normal. This is the first report of bacteremia caused by in China. The findings could improve the awareness and attention of the rare pathogenic microorganisms in China.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247281 | PMC |
| http://dx.doi.org/10.3389/fcimb.2022.882827 | DOI Listing |
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