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| http://dx.doi.org/10.5152/TurkArchPediatr.2022.22031 | DOI Listing |
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Efficacy of non-cultured non-trypsinized dermabraded epidermal cell graft followed by narrowband ultraviolet B phototherapy in stable vitiligo.
J Cutan Aesthet Surg
February 2025
Department of Dermatology, Venereology, and Leprosy, GSL Medical College, Rajahmahendravaram, Andhra Pradesh, India.
Objectives: The objective of this study was to evaluate the efficacy and adverse effects of non-cultured, nontrypsinized dermabraded epidermal cell graft followed by narrowband ultraviolet B (NB-UVB) therapy for stable vitiligo.
Material And Methods: A hospital-based and prospective interventional study was carried out on 45 patients (18-65 years) of both genders after approval from the Ethics Committee. The donor site was dermabraded after applying mupirocin ointment, and the material obtained was spread over the dermabraded recipient site.
Atypical Bilateral Hyperpigmented Macules on the Lower Legs Possibly due to Cyclophosphamide.
Case Rep Dermatol
December 2024
Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Introduction: Chemotherapeutic agents occasionally induce various cutaneous adverse events, but hyperpigmentation due to cyclophosphamide is extremely rare.
Case Presentation: A case of atypical bilateral hyperpigmented macules on the lower legs possibly due to cyclophosphamide was presented. A physical examination on his initial visit revealed xerotic skin exhibiting brownish discoloration with black scales on both lower legs.
Thiotepa-Induced Toxicity: A Clinical Mimic of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Featuring Severe Mucositis, Diffuse Dusky Discoloration, and Skin Sloughing.
Am J Dermatopathol
April 2025
Department of Pathology & Microbiology, University of Nebraska Medical Center, Omaha, NE.
Background: Thiotepa, an alkylating agent commonly used in chemotherapy, is increasingly recognized to induce cutaneous reactions resembling toxic erythema of chemotherapy (TEC). This condition is characterized by erythema, hyperpigmentation, and mucositis, often affecting intertriginous areas, and can mimic the early stages of Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN).
Case Description: A 31-year-old woman with a history of systemic lupus erythematosus, antiphospholipid antibody syndrome, seizures, and chronic kidney disease was admitted for the management of central nervous system (CNS) lymphoma.
Secondary open-angle glaucoma as an initial presentation of diffuse iris melanoma.
BMJ Case Rep
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Ophthalmology, KU Leuven University Hospitals Leuven, Leuven, Flanders, Belgium
We present a case of unilateral, secondary open-angle glaucoma due to an underlying diffuse iris melanoma. The patient was referred by his ophthalmologist with uncontrolled, elevated intraocular pressure in the left eye. He had been treated for asymmetric open-angle glaucoma for over a year prior to referral.
View Article and Find Full Text PDFNanocrystals in Dermal Drug Delivery: A Breakthrough for Enhanced Skin Penetration and Targeted Skin Disorder Treatments.
Pharmaceutics
December 2024
Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia.
One of the major challenges in dermal drug delivery is the adequate penetration of the active compound into the skin without causing any skin irritation and inflammation. Nanocrystals (NCs) are nanoscale particles, and their sizes are below 1000 nm. NCs are made up of drug particles only, which are used to improve the aqueous solubility and bioavailability of poorly water-soluble drugs.
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