AI Article Synopsis
- - Rhuleave-K™ is a blend of Curcuma longa extract, Boswellia serrata extract, and black sesame seed oil, whose safety was tested through acute and sub-chronic toxicity studies on rats.
- - In the acute study, rats were given a maximum dose of 2000 mg/kg, with no signs of toxicity or mortality observed, leading to an LD50 greater than 2000 mg/kg.
- - During the 90-day sub-chronic study at doses of 100, 500, and 1000 mg/kg/day, no toxic effects were observed; the NOAEL (No Observed Adverse Effect Level) was established at 1000 mg/kg daily.
Article Abstract
Rhuleave-K™ is a proprietary combination of Curcuma longa extract, Boswellia serrata extract and black sesame seed oil. Acute toxicity was evaluated as per OECD guidelines 423. Rhuleave-K™ was fed at 2000 mg/kg to overnight fasted female rats. Clinical signs of abnormality and mortality was observed daily for 14 days. Sub-chronic toxicity was studied by feeding Rhuleave-K™ at 100, 500 and 1000 mg/kg/day to rats as per OECD guidelines 408. After 90 days feeding, hematological and biochemical parameters were analyzed. Histopathology of all the major organs was also studied. In the acute toxicity study, there was no clinical sign of toxicity in any of the rats at maximum dose of 2000 mg/kg. The LD50 was computed as >2000 mg/kg in rats. The repeated dosing of Rhuleave-K™ at the maximum dose level of 1000 mg/kg for 90 days did not induce any observable toxic effects in rats, when compared to its corresponding control. The hematology and biochemistry profiles of treated rats were similar to control animals and difference was non-significant (p > 0.05). The histopathology of major organs of all the control and treated animals was normal. In this study the NOAEL for Rhuleave-K™ was calculated as 1000 mg/kg daily in rats.
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| http://dx.doi.org/10.1016/j.yrtph.2022.105214 | DOI Listing |
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