Impact of environmental phthalate on human health and their bioremediation strategies using fungal cell factory- A review.

Phthalates are utilized as plasticizers in plastic products to enhance their durability, transparency, and elasticity. However, phthalates are not covalently bonded to the polymer matrix of the phthalate-containing products and can be gradually released into the environment through biogeochemical processes. Hence, phthalates are now pervasive in our environment, including our food. Reports suggested that phthalates exposure to the mammalian systems is linked to various health consequences. It has become vital to develop highly efficient strategies to reduce phthalates from the environment. In this context, the utilization of fungi for phthalate bioremediation (mycoremediation) is advantageous due to their highly effective enzyme secretory system. Extracellular and intracellular enzymes of fungi are believed to break down the phthalates by ester hydrolysis to produce phthalic acid and alcohol, and subsequent digestion of the benzene rings of phthalic acid and their metabolites. The present review scrutinizes and highlights the knowledge gap in phthalate prevalence, exposure to mammals, and associated human health challenges. Furthermore, discusses the role of fungi and their secretory enzymes in the biodegradation of phthalates and gives a perspective to better describe and tackle this continuous threat.