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http://dx.doi.org/10.1016/j.clnu.2022.06.015 | DOI Listing |
Front Mol Neurosci
February 2023
School of Health Sciences, College of Health, Massey University, Wellington, New Zealand.
Clin Nutr
August 2022
Second Medical Clinic, School of Medicine, Ippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki 54642, Macedonia, Greece; Division of Gastroenterology and Hepatology, Medical University Department, Kantonsspital Aarau, Aarau 5001, Switzerland.
Int J Dermatol
October 2022
Dermatology Clinic, Department of Medical Sciences, University of Turin, Turin, Italy.
Clin Cancer Res
January 2022
Division of Oncology, Rambam Health Care Campus, Haifa, Israel.
Purpose: In this first-in-human study (NCT03564691) in advanced solid tumors, we investigated a novel first-in-class human IgG4 monoclonal antibody targeting the immunoglobulin-like transcript 4 (ILT4) receptor, MK-4830, as monotherapy and in combination with pembrolizumab.
Patients And Methods: Patients with histologically/cytologically confirmed advanced solid tumors, measurable disease by RECIST v1.1, and evaluable baseline tumor sample received escalating doses of intravenous MK-4830 every 3 weeks as monotherapy (parts A and B) and in combination with pembrolizumab (part C).
Clin Cancer Res
September 2019
Early Drug Development Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Purpose: STM 434 is a soluble receptor ligand trap targeting activin A, a protein in the TGFβ family that plays important roles in growth, differentiation, and cancer cachexia. This study evaluated the safety, antitumor activity, and metabolic effects of STM 434 in a first-in-human, multicenter, phase I clinical trial (NCT02262455).
Patients And Methods: Patients with advanced solid tumors were enrolled in 8 dose cohorts ranging from 0.
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