Two men with metastatic paraganglioma/pheochromocytoma underwent PET/CT examination in our hospital to understand the treatment effect and progression of the disease. Both patients had previously been treated with 131 I-MIBG, and at this evaluation, both of them underwent 68 Ga-DOTATATE and 18 F-MFBG PET/CT. The 68 Ga-DOTATATE PET/CT showed more metastases in the images of these 2 patients. This case highlighted that 68 Ga-DOTATATE PET/CT is superior to 18 F-MFBG PET/CT in detecting metastases from paraganglioma and pheochromocytoma in these 2 patients.
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