Cationic nonribosomal lipopeptides (CNRLPs) from spp. have been a rewarding source of Gram-negative-active antibiotics. Here we systematically screened sequenced bacterial genomes for CNRLP biosynthetic gene clusters (BGCs) that we predicted might encode additional Gram-negative-active antibiotics. Total chemical synthesis of the bioinformatically predicted products of seven such BGCs led to our identification of new laterocidine, tridecaptin, and paenibacterin-like antibiotics with potent activity against both multiple-drug-resistant Gram-negative and Gram-positive pathogens.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10234496 | PMC |
| http://dx.doi.org/10.1021/acs.orglett.2c01879 | DOI Listing |
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